Role of Pentraxin-3 in Periodontal Inflammation - A Comprehensive Review
Syed Wali Peeran, Ahmed Elhassan, Tazeen Dawood, Karthikeyan Ramalingam, Syed Ali Peeran, Fatma Ahmed, Abdul-Aziz Ahmed A. Adawi
Journal of Pharmaceutical Research International · pp. 209–219 · Published 13 Dec 2021
10.9734/jpri/2021/v33i55A33824Abstract
Acute phase reactants like C-reactive protein (CRP), and pentraxin 3 (PTX3) are increased with inflammation and tissue injury. PTX3 is an acute phase protein and a member of the long pentraxin family. CRP is synthesized in the liver but PTX3 is generated locally at the inflammatory site. It is a fluid-phase pattern-recognition molecule that regulates antimicrobial immunity and inflammation by interfering with selectin-dependent neutrophil recruitment and regulating the complement cascade. Hence, PTX3 could be used as a potential biomarker to identify inflammatory response in both acute and chronic diseases. In this review, we discuss the role of PTX3 in periodontal inflammation.
Cited by 6
W. Dong, D. Guo, C. Yang · Journal of Dental Research · 2025
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Sivaraman Prakasam, Justin Merritt, Jens Kreth · Current Oral Health Reports · 2022
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