Rhoifolin; A Potent Antiproliferative Effect on Cancer Cell Lines
Journal of Pharmaceutical Research International · pp. 46–53 · Published 19 Dec 2012
10.9734/BJPR/2013/1864Abstract
Aims: To investigate the cytotoxic activity of rhoifolin against different cancer cell lines. Study Design: Isolation, identification and cytotoxic activity evaluation. Place and Duration of Study: Faculty of Pharmacy, Ain Shams University and Al-Azhar University, between October, 2010 and January, 2011. Methodology: Rhoifolin, Apigenin 7-O-β neohesperidoside was isolated in a copious amount from the leaves of Chorisia crispiflora (Bombaceae). Its identity was unambiguously confirmed via different spectroscopic methods (UV, 1HNMR, 13CNMR and HMBC) and viability assay test was used to evaluate its cytotoxic activity. Results: It exhibited potent anticancer activities, nearly similar to that of vinblastine, when evaluated against human epidermoid larynex (Hep 2) and human cervical (HeLa) carcinoma cell lines. Promising activities were also obtained against hepatocellular (Hep G2), colon (HCT-116) and fetal human lung fibroblast (MRC-5) carcinoma cell lines. A unique effect of rhoifolin was in having no cytotoxic activity against healthy normal cells (Vero cells) which indicates a high selectivity of this compound. Conclusion: The findings of this study showed that rhoifolin could be used as an ideal anticancer agent. It discriminates between cancerous and non cancerous cell as it kills only the former one. So the side effects which may appear during chemotherapy could be overcome.
Cited by 39
Alaa M. Hammad, Suhair Sunoqrot, Thanaa Al-zuhd · Metabolic brain disease · 2025
Hanghang Du, Hao-Feng Xiong, Shi Zeng · International Journal of Biological Macromolecules · 2025
C. S. Kılıç, Mehmet Murat Kişla, Gulin Amasya · EXCLI Journal : Experimental and Clinical Sciences · 2025
Engy Saadalah Ibrahem, J. Fahim, M. Samy · Chemistry · 2025
Hai-Bo Yang, Bingbing Li, Guoqiang Fan · Industrial crops and products (Print) · 2024
Ion Brînza, R. Boiangiu, M. Mihăşan · European Journal of Pharmacology · 2024
Jiangmei Hu, Jun-Huo Cai, Xinrui Hu · Horticulturae · 2024
Xin-Min Huang, Xiaoli Liu, Qi Wang · PeerJ · 2024
J. Fahim, Engy A. Ibrahim, M. Samy · Journal of advanced Biomedical and Pharmaceutical Sciences · 2023
M. Marzouk, Shimaa M. Khalifa, Amal H. Ahmed · Bioorganic chemistry (Print) · 2023
Related research
- Evaluation of the Antioxidant, Analgesic and Cytotoxic Activities of Daucus carota canopy L Ethanolic Extract — shares topic coverage
- A Novel Catalytic Synthesis of Flavones under Autoclave Conditions and Comparative Study of Anti-cancer Activity — shares topic coverage
- Evaluation of Analgesic, Antidiarrhoeal and Cytotoxic Activities of Ethanolic Extract of Bacopa monnieri (L) — shares topic coverage
- Phytochemical Investigation and Molecular Profiling by p21 and NF-κB of Chorisia crispiflora Hexane Extract in Human Breast Cancer Cells in Vitro — shares topic coverage
- Impact of Processing Temperature and Time Variability on Nutrient and Oil Profile of Edible African Termites (Macrotermes nigeriensis) — shares topic coverage
Article metrics
Real usage data collected on this platform.
60
Page views
0
PDF downloads
4
Outbound clicks
39
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.