Reversal of Hypertension and Amelioration of Oxidative Stress by Persea americana and Allium sativum in Experimentally-Induced Hypertensive Wistar Rats
Olayinka A. Oridupa, Sunday Adefila, Mordiyah Aliyu, Tolulope A. Olakojo, Ayobami D. Obisesan
European Journal of Medicinal Plants · pp. 42–52 · Published 25 Jan 2023
10.9734/ejmp/2023/v34i11119Abstract
Aim: This study evaluated the antihypertensive and antioxidant effects of hexane, ethyl acetate and methanol extracts of Persea americana and Allium sativum in experimentally-induced hypertensive Wistar rats. Study Design: Experimental Research. Place and Duration of Study: Department of Veterinary Pharmacology and Toxicology, University of Ibadan (Animal House), between May 2019 and December 2019. Methodology: The experiment was carried out in 85 rats randomly divided into 17 groups. Group 1 were normotensive rats while hypertension was induced in groups 2-16 by unilateral nephrectomy and inclusion of NaCl (1%) in drinking water. Group 17 had abdominal incision without nephrectomy (sham). Treatment groups were administered P. americana or A. sativum extracts at 20 mg/kg or 50 mg/kg dose and standard antihypertensives; lisinopril or hydrochlorothiazide. Results: Results of the experiment showed treatment of hypertensive rats with 50 mg/kg of A. sativum hexane and P. americana methanol extract caused the most significant decrease in blood pressure compared to normotensive rats. Various extracts of these two plants elevated antioxidants levels (GPx, GST, GSH and SOD) in the brain, heart, kidney and liver significantly while H2O2 and MDA were significantly decreased compared to untreated hypertensive rats. NO, an important neurotransmitter for normal endothelial function was also restored in the extract-treated rat, as a deficiency contributes greatly to the development of hypertension. Conclusion: The study concluded that P. americana and A. sativum do not only lower blood pressure. The plants also inhibited generation of free radicals by enhancing the antioxidant system and mopped up generated free radicals demonstrated by decline in H2O2 and MDA levels. These plants have been shown in this study to contain potential drug candidates which can be proposed for treatment of hypertension.
References (31)
- 1 Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal [DOI]
- 2 Antioxidants and antioxidant methods: an updated overview [DOI]
- 3 Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases [DOI]
- 4 Vascular NAD(P)H oxidases: specific features, expression, and regulation [DOI]
- 5 Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management [DOI]
- 6 The role of oxidative stress in the pathophysiology of hypertension [DOI]
- 7 Oxidative Stress and Antioxidants in Hypertension–A Current Review [DOI]
- 8 Role of Nitric Oxide in the Cardiovascular and Renal Systems [DOI]
- 9 Cardiovascular roles of nitric oxide: A review of insights from nitric oxide synthase gene disrupted mice [DOI]
- 10 Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance [DOI]
- 11 Essential hypertension and oxidative stress: New insights [DOI]
- 12 Reactive Oxygen Species and Cellular Defense System [DOI]
- 13 The role of NADPH oxidases in infectious and inflammatory diseases [DOI]
- 14 Garlic Reduces Dementia and Heart-Disease Risk [DOI]
- 15 Free Radicals in Human Health and Disease [DOI]
- 16 Oxidative Stress in Neutrophils: Implications for Diabetic Cardiovascular Complications [DOI]
- 17 Homocysteine and Essential Hypertension [DOI]
- 18 Glutathione Peroxidase-1 Plays a Major Role in Protecting Against Angiotensin II–Induced Vascular Dysfunction [DOI]
- 19 Oxidative‐Stress Biomarkers in Patients with Pulmonary Hypertension [DOI]
- 20 Serum Superoxide Dismutase Is Associated with Vascular Structure and Function in Hypertensive and Diabetic Patients [DOI]
- 21 Exercise Training, NADPH Oxidase p22phox Gene Polymorphisms, and Hypertension [DOI]
- 22 Pathophysiology of Hypertension in the Absence of Nitric Oxide/Cyclic GMP Signaling [DOI]
- 23 Two new stereoisomeric antioxidant triterpenes from Potentilla fulgens [DOI]
- 24 In vitro and In vivo Antioxidant evaluation and estimation of total phenolic, flavonoidal content of Mimosa pudica L [DOI]
- 25 Antihypertensive properties of Allium sativum (garlic) on normotensive and two kidney one clip hypertensive rats.
- 26 Incremental predictive value of carotid intima–media thickness to arterial stiffness for impaired coronary flow reserve in untreated hypertensives [DOI]
- 27 Effects of chronic ethanol exposure on renal function tests and oxidative stress in kidney [DOI]
- 28 Glutathione system in young spontaneously hypertensive rats [DOI]
- 29 Lipoproteins and Cardiovascular Diseases [DOI]
- 30 Potent antitumor property of Allium bakhtiaricum extracts [DOI]
- 31 Biochemical Effects of Aqueous Extract of Persea americana (Mill) on the Myocardium of Left Ventricle of High Salt–Fed Adult Wistar Rats [DOI]
Cited by 0
No indexed citations yet.
Related research
- In vitro Antioxidant and Anticancer Activity of Cyanobacteria — shares topic coverage
- Review: Parkia speciosa as Valuable, Miracle of Nature — shares topic coverage
- A Selective Review of Lipid Autoxidation and Rancidity, Antioxidants, and Dithiooxamide — shares topic coverage
- Antioxidant and Haemato-Biochemical Enhancing Properties of Daucus carota in Male Wistar Rats Toxicated with Lead Chloride — shares topic coverage
- Radical Scavenging Capacity and Efficacy of Myristica fragrans (Nutmeg) Metabolites on Cladosporum herbarum of Food Origin — shares topic coverage
Article metrics
Real usage data collected on this platform.
70
Page views
0
PDF downloads
41
Outbound clicks
0
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.