Relationship of C-reactive Protein to Lymphocyte Ratio with Prognosis and Mortality in COVİD 19

Abstract

Background: The Covid 19 pandemic is a serious disease that has infected millions of people and died tens of thousands. The clinical findings of the disease is observed in a wide range from asymptomatic to death. On the other hand, abnormal pathological variety is findings in laboratory parameters. Aims: In this study, it was aimed to relation  laboratory parameters with prognosis and mortality in the admission intensive care. Study Design: This study was done in Ersin Arslan Training and Research Hospital Covid Intensive-care unit between July 1, 2021 and September 30, 2021. Methodology: Patients over the age of 18 who were positive Polymerase Chain Reaction test and admitted in the intensive-care unit were included in the study. The data of a total of 197 patients who were compatible with this criteria was retrospectively analyzed. White blood cells, C-reactive protein, procalcitonin and lymphocyte values (within the first 24 hours) ​​of the patients, use history of steroid, and whether they were intubated and their mortality were investigated.The relations of the obtained data with each other were evaluated. Statistical analysis was performed using the Wilcoxon Signed-Rank test. Results: 113 were males (57.3%), and 84 were females (42.7%). The mean age was 64.6 ±2.16 (21-95) years.  Most of the patients (67.5%) were over 60 years old. WBC values ​​of the patients were 46.8% high and 53.2% normal (normal value range 4-10 μL). Lymphocyte values were 55.3% lymphopenia, 43.6% normal lymphocytes, 1.1% lymphocytosis (normal value range 0.8-4 μL). CRP results were 98.9% high (normal value range 0-5 mg/L). High PCT value was 26.3% of the patients (normal value range 0-0.5 ng/ml). 86.8% of the patients were used steroids. 58.3% intubated (in Intensive-care unit) and 54.8% died of the patients. According to the lower and upper reference values; WBC/Lymphocyte:1-12.5 and CRP/Lymphocyte: 0-6.25 values ​​were accepted normal ranges. Conclusion: Mortality is more often in patients with females and over 60 years of age admitted to the intensive-care unit in Covid-19. If the CRP to Lymphocyte ratio is more than 100, it is related with mortality.