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Research Article Open access CC BY 4.0

Quorum Sensing Inhibitors: The Novel Bacterial Infection Disrupting Agents

Suha M. Abudoleh, Adel M. Mahasneh

Microbiology Research Journal International · pp. 1–18 · Published 7 Jul 2016

10.9734/BMRJ/2016/27009

Abstract

With increasing misuse of antimicrobial substances in medical settings, it became imminent to search for alternative pathogen control means to aid in preventing disease spread. Among such alternatives is the action upon virulent gene expression of the pathogen itself. A possible approach in this direction is the search for quorum sensing inhibitors from different components of the environment. In the last decade, a great interest in the search for new and novel anti-quorum sensing substances from plant and microbial origin has been observed. In this review, we are trying to follow up what has been published in this direction showing areas of interest for researchers to follow.

Quorum sensing autoinducers bacterial biofilm Chromobacterium violaceum

References (68)

  1. 1 Mechanisms of biofilm resistance to antimicrobial agents [DOI]
  2. 2 Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators [DOI]
  3. 3 Antimicrobial agents and chemotherapy—1969 [DOI]
  4. 4 Bacterial Quorum-Sensing Network Architectures [DOI]
  5. 5 Analytical and bioanalytical chemistry
  6. 6 Bacterial Extracellular Polysaccharides Involved in Biofilm Formation [DOI]
  7. 7 From the Philosophical Transactions of The Royal Society [DOI]
  8. 8 Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound [DOI]
  9. 9 Quorum sensing inhibitors: An overview [DOI]
  10. 10 Look who's talking: communication and quorum sensing in the bacterial world [DOI]
  11. 11 LuxS quorum sensing: more than just a numbers game [DOI]
  12. 12 Current Topics in Microbiology and Immunology [DOI]
  13. 13 Quorum Sensing Inhibitors Increase the Susceptibility of Bacterial Biofilms to Antibiotics In Vitro and In Vivo [DOI]
  14. 14 Quorum sensing in bacterial virulence [DOI]
  15. 15 Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice [DOI]
  16. 16 Inhibition of bacterial quorum sensing by vanilla extract [DOI]
  17. 17 Quorum Sensing Inhibitors as Anti-Biofilm Agents [DOI]
  18. 18 International Journal of Molecular Science
  19. 19 Antibiofilm and quorum sensing inhibitory potential of Cuminum cyminum and its secondary metabolite methyl eugenol against Gram negative bacterial pathogens [DOI]
  20. 20 Bacterial cell-to-cell communication: sorry, can't talk now — gone to lunch! [DOI]
  21. 21 Quorum Sensing and Quorum Quenching: The Yin and Yang of Bacterial Communication [DOI]
  22. 22 Quorum sensing and signal interference: diverse implications [DOI]
  23. 23 Anti-quorum sensing activity of medicinal plants in southern Florida [DOI]
  24. 24 Inhibition of quorum sensing regulated bacterial functions by plant essential oils with special reference to clove oil [DOI]
  25. 25 Quorum sensing in biofilms – How to destroy the bacterial citadels or their cohesion/power? [DOI]
  26. 26 Development of Novel Drugs from Marine Surface Associated Microorganisms [DOI]
  27. 27 Antimicrobial, Cytotoxicity and Phytochemical Screening of Jordanian Plants Used in Traditional Medicine [DOI]
  28. 28 Jamming bacterial communication: New approaches for the treatment of infectious diseases [DOI]
  29. 29 Quorum Sensing Antagonism from Marine Organisms [DOI]
  30. 30 Biofilm Development with an Emphasis on Bacillus subtilis [DOI]
  31. 31 Screening of traditional Chinese medicinal plants for quorum-sensing inhibitors activity [DOI]
  32. 32 Plant–microbe interactions: identification of epiphytic bacteria and their ability to alter leaf surface permeability [DOI]
  33. 33 Cross‐species induction and enhancement of antimicrobial activity produced by epibiotic bacteria from marine algae and invertebrates, after exposure to terrestrial bacteria [DOI]
  34. 34 Paradigm Shift in Discovering Next-Generation Anti-Infective Agents: Targeting Quorum Sensing, C-Di-Gmp Signaling and Biofilm Formation in Bacteria with Small Molecules [DOI]
  35. 35 History of antimicrobial agents and resistant bacteria.
  36. 36 Chemical Signaling among Bacteria and Its Inhibition [DOI]
  37. 37 Quorum-sensing inhibitory compounds from extremophilic microorganisms isolated from a hypersaline cyanobacterial mat [DOI]
  38. 38 In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect [DOI]
  39. 39 Quorum sensing inhibitory drugs as next generation antimicrobials: Worth the effort? [DOI]
  40. 40 Assessment of Anti-Quorum Sensing Activity for Some Ornamental and Medicinal Plants Native to Egypt [DOI]
  41. 41 Quorum sensing inhibitors from Leucetta chagosensis Dendy, 1863 [DOI]
  42. 42 Small molecule screen yields inhibitors of pseudomonas homoserine lactone-induced host responses [DOI]
  43. 43 Microbiology: Breaking Down Biofilms [DOI]
  44. 44 Quorum-sensing: The phenomenon of microbial communication
  45. 45 Bioactive proteins from Solanaceae as quorum sensing inhibitors against virulence in Pseudomonas aeruginosa [DOI]
  46. 46 Quorum Sensing Inhibitors as Anti-Pathogenic Drugs in the Fight Against Pseudomonas aeruginosa Infections [DOI]
  47. 47 Beyond quorum sensing: the complexities of prokaryotic parliamentary procedures [DOI]
  48. 48 Screening and isolating quorum sensing inhibitor from bacteria [DOI]
  49. 49 Applied and Environmental Microbiology [DOI]
  50. 50 Bacterial physiology: a molecular approach [DOI]
  51. 51 THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY [DOI]
  52. 52 Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors [DOI]
  53. 53 MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS [DOI]
  54. 54 Bacterial Quorum Sensing in Pathogenic Relationships [DOI]
  55. 55 Quorum sensing by peptide pheromones and two‐component signal‐transduction systems in Gram‐positive bacteria [DOI]
  56. 56 Identity and effects of quorum-sensing inhibitors produced by Penicillium species [DOI]
  57. 57 Quorum sensing: the many languages of bacteria [DOI]
  58. 58 Messing with Bacterial Quorum Sensing [DOI]
  59. 59 FEMS Immunology and Medical Microbiology [DOI]
  60. 60 Synthetic quorum-sensing circuit to control consortial biofilm formation and dispersal in a microfluidic device [DOI]
  61. 61 The RNPP family of quorum-sensing proteins in Gram-positive bacteria [DOI]
  62. 62 Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections [DOI]
  63. 63 Quorum-Sensing Inhibitors and Biofilms [DOI]
  64. 64 Size of quorum sensing communities [DOI]
  65. 65 Antimicrobial and Antiquorum Sensing Activity of Different Parts of Laurus nobilis L. Extracts
  66. 66 African Journal of Microbiology Research [DOI]
  67. 67 Current Infectious Disease Reports [DOI]
  68. 68 International Journal of Bacteriology [DOI]

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