Synthetic Approaches to Steroidal Thiosemicarbazones, 1,3,4-Thia(selena)diazolines, and Oxalate-Linked Dimers

References (37)

1. 1 Puerta, 2025, Development of steroidal spiro-heterocycles through one-step cyclocondensation, their evaluation as antiproliferative agents
2. 2 Dembitsky, V.M. (2023). Steroids bearing heteroatom as potential drugs for medicine. Biomedicines, 11. [DOI]
3. 3 Cortés-Percino, A., Vega-Báez, J.L., Romero-López, A., Puerta, A., Merino-Montiel, P., Meza-Reyes, S., Padrón, J.M., and Montiel-Smith, S. (2019). Synthesis and evaluation of pyrimidine steroids as antiproliferative agents. Molecules, 24. [DOI]
4. 4 Sharma, 2023, Formation of nitrogen-containing six-membered heterocycles on steroidal ring system: A review [DOI]
5. 5 Asiri, 2010, Palladium (II) complexes of NS donor ligands derived from steroidal thiosemicarbazones as antibacterial agents [DOI]
6. 6 Pavan, 2010, Thiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/hydrazones: Anti-Mycobacterium tuberculosis activity and cytotoxicity [DOI]
7. 7 Khan, 2017, Synthesis and spectroscopic studies of Ru(II) complexes of steroidal thiosemicarbazones by multistep reaction: As antibacterial agents [DOI]
8. 8 Petrasheuskaya, T.V., Kovacs, F., Igaz, N., Ronavari, A., Hajdu, B., Bereczki, L., May, N.V., Spengler, G., Gyurcsik, B., and Kiricsi, M. (2023). Estradiol-based salicylaldehyde (thio)semicarbazones and their copper complexes with anticancer, antibacterial and antioxidant activities. Molecules, 28. [DOI]
9. 9 Jankovic, D.D., Sestic, T.L.J., Bekic, S., Savoic, M.P., Celic, A.S., Sholda, J., Kopp, F., Marinovic, M., Petri, E.T., and Adjukovic, J.J. (2024). Development of new steroid-based hydrazide and (thio)semicarbazone compounds with anticancer properties. J. Steroid Biochem. Mol. Biol., 242. [DOI]
10. 10 Bai, C., Wu, S., Ren, S., Zhu, M., Luo, G., and Xiang, H. (2021). Synthesis and evaluation of novel thiosemicarbazones and semicarbazone analogs with both anti-proliferative and anti-metastatic activities against triple negative breast cancer. Bioorg. Med. Chem. Lett., 37. [DOI]
11. 11 Melones-Herrero, J., Aguilar-Rico, F., Matesanz, A.I., Calés, C., Sanchez-Perez, I., and Quiroja, A.G. (2025). Antiproliferative activity in breast cancer cells of PtL2: Steroid-thiosemicarbazone platinum(II) complex. J. Inorg. Biochem., 270. [DOI]
12. 12 Aqlan, 2022, Thiazolidinone: A structural motif of great synthetic and biological importance [DOI]
13. 13 Afzal, 2025, Design, synthesis and characterization of novel thiazolidinone derivatives: Insights from a network pharmacology approach for breast cancer therapy [DOI]
14. 14 Dewangan, 2024, Imidazolidinone derivatives as pioneering anticancer agents: Unraveling insights through synthesis and structure–activity exploration [DOI]
15. 15 Mukhrish, 2025, Exploring the cyclization of thiosemicarbazone to 1,3,4-thiadiazole: Synthesis, characterization and in-silico study [DOI]
16. 16 Ahamad, 2024, A review on recent progress in synthesis and biological activities of thiadiazole and its derivatives [DOI]
17. 17 Borcea, A.M., Lonut, L., Crisan, O., and Oniga, O. (2021). An overview of the synthesis and antimicrobial, antiprotozoal, and antitumor activity of thiazole and bisthiazole derivatives. Molecules, 26. [DOI]
18. 18 Parsekar, 2022, Synthesis, characterization, crystal structure, DNA and HSA interactions, and anticancer activity of a mononuclear Cu(II) complex with a Schiff base ligand containing a thiadiazoline moiety [DOI]
19. 19 Toan, 2021, 1,3,4-Thiadiazoline–coumarin hybrid compounds containing D-glucose/D-galactose moieties: Synthesis and evaluation of their antiproliferative activity [DOI]
20. 20 Kubota, 1980, Synthesis of 4-acyl-2-(acylamino)-Δ2-1,3,4-thiadiazolines and 4-acyl-2-amino-Δ2-1,3,4-thiadiazolines by acylation of thiosemicarbazones [DOI]
21. 21 Petri, 2025, Heterocyclic Androstane Derivatives Targeting Hormone-related Cancers: Synthesis, Bioactivity and Docking Studies [DOI]
22. 22 Huang, 2017, Synthesis and antiproliferative activity of novel A-homo-B-norsteroid thiadiazole derivatives [DOI]
23. 23 Plata, 2017, New selenosteroids as antiproliferative agents [DOI]
24. 24 Duax, 1975, Conformational studies of steroids: Correlations with biological data [DOI]
25. 25 Ertl, P., Altmann, E., and Racine, S. (2023). The most common linkers in bioactive molecules and their bioisosteric replacement network. Bioorg. Med. Chem., 81. [DOI]
26. 26 Alexis, 2019, Naphthol-derived Betti bases as potential SLC6A14 blockers [DOI]
27. 27 Méndez Delgado, L.A. (2018). Síntesis de Nuevos Derivados Esteroidales Diméricos de Interés Biológico. [Master’s Thesis, Benemérita Universidad Autónoma de Puebla]. Available online: https://dgb-buap.primo.exlibrisgroup.com/discovery/fulldisplay?docid=alma991004419342508991&context=L&vid=52BUADP_INST:52BUADP&lang=es.
28. 28 Cui, 2016, Synthesis and biological evaluation of D-ring fused 1,2,3-thiadiazole dehydroepiandrosterone derivatives as antitumor agents [DOI]
29. 29 Suhr, 2003, Synthesis of dihydrodiosgenin glycosides as mimetics of bidesmosidic steroidal saponins [DOI]
30. 30 Brunck, 2000, Synthesis of cytostatic tetradecacyclic pyrazines and novel reduction-oxidation sequence for spiroketal opening in sapogenins [DOI]
31. 31 Leng, 2010, Synthesis and anti-glioma activity of 25(R)-spirostan-3β-5α,6β,19-tetrol [DOI]
32. 32 Shawakfeh, 2010, Synthesis of new di- and triamine diosgenin dimers [DOI]
33. 33 Maza, 2009, Synthesis of sugar-derived isoselenocyanates, selenoureas and selenazoles [DOI]
34. 34 Mays, 2008, Identification, synthesis, and enzymology of non-natural glucosinolate chemopreventive candidates [DOI]
35. 35 Khan, 2012, Novel steroidal (6R)-spiro-1,3,4-thiadiazoline derivatives as anti-bacterial agents [DOI]
36. 36 Khan, 2012, Synthesis and in vitro antibacterial activity of novel steroidal (6R)-spiro-1,3,4-thiadiazoline derivatives [DOI]
37. 37 2019, Synthesis of symmetrical and hybrid dimeric steroids by double Suzuki–Miyaura cross-coupling of 4-bromo-3-oxo steroids and benzene-1,4-diboronic acid [DOI]

Cited by 2

2 citations reported by external sources — individual citing-article records aren't available to list yet.

Related research

• A Novel Catalytic Synthesis of Flavones under Autoclave Conditions and Comparative Study of Anti-cancer Activity — shares topic coverage
• Thermostability and in-vitro Antibacterial Activity of Aqueous Extracts of Tetrapleura tetraptera Pods on Multidrug Resistant Clinical Isolates — shares topic coverage
• Acute Toxicity, Phytochemistry and Anti-diarrheal Effects of Celtis integrifolia Lam. Aqueous Leaf Extract in Wistar Albino Rats — shares topic coverage
• Understanding the Reactivity of Trimethylsilyldiazoalkanes Participating in [3+2] Cycloaddition Reactions towards Diethylfumarate with a Molecular Electron Density Theory Perspective — shares topic coverage
• Understanding the Origin of the Regioselectivity in Non-Polar [3+2] Cycloaddition Reactions through the Molecular Electron Density Theory — shares topic coverage