Plants Phenolics as Possible Pseudomonas aeruginosa Resistance Inhibitors

Abstract

Pseudomonas aeruginosa virulence has for long been a serious medical, economic and social problem. It is responsible for numerous nosocomial infections like pneumonia, urinary tract infections, surgical site infections and some of community-acquired infections such as otitis, ulcerative keratitis and soft tissue infections. Its ability of adhering to various kinds of surfaces, such as hospital and surgical materials (thus: implicated in causing nosocomial infections) is one of the many reasons why P. aeruginosa is of utmost medical and economic importance. This bacterium has an extensive adaptive capability to different kinds of physical surfaces and conditions. P. aeruginosa has high capability for the formation of resistant biofilms and the regulation of efflux pumps, thus; these two contributes highly towards an elevated resistance to numerous antibiotics. Several antibiotic resistance genes are responsible for P. aeroginosa drug resistance virulence. Plant phenolics have the ability to bind to protein and non-protein domains leading to modification or inhibition protein–protein/co-factor interactions. These are a diverse group of aromatic secondary metabolites involved in plant defense. P. aeruginosa resistance genes mechanisms and evasion tactics can be affected and neutralized by ethno-plant secondary metabolites especially Phenolics, in several different ways due to the nature of its inter-molecular interactions. Ethno-plant phenolics could really provide an alternative natural remedy for the management and neutralization of P. aeruginosa Multi-drug resistance Genes.