Hepatoprotective Effect of Ginseng, Green Tea, Cinnamon Their Combination against Acetamiprid - induced Oxidative Stress in Rats

Abstract

The present study aimed to investigate whether ginseng, green tea and cinnamon or/and mixture can improve liver in a rats and whether this therapeutic approach resulted in amelioration in lipids profile (serum cholesterol, triglycerides, Serum HDL, Serum LDL, FT3 and FT4), liver function profile (serum aspartate transaminase, alanine transaminase, total protein and albumin) and cytokines profile (serum tumor necrosis factor-α, interleukin-1ß and interleukin-6). Male albino rats weighing 150 g ± 10% were used. They were divided into two groups: negative control and Acetamiprid groups. The results demonstrated that Acetamiprid induced antioxidant and biochemical alterations at testing periods 15 and 30 days. The obtained results revealed a significant (P<0.001) increase in Lipid parameters in Acetamiprid rats than those in their control ones. Lipid parameters (serum cholesterol, triglycerides, free fatty acids & cholesterol) were significantly (P<0.001) elevated in Acetamiprid rats compared with their corresponding control group. On the other hand, induction of Acetamiprid to rats caused a significant (P<0.001) decrease in adiponectin level. Liver function tests (serum aspartate transaminase and alanine transaminase) were significantly (P<0.001) increased in Acetamiprid rats compared with their corresponding control group But, the levels of serum total protein and albumin were remarkably decreased in Acetamiprid rats group. A considerable (P<0.001) elevation were occurred in all cytokines parameters (serum tumor necrosis factor-α, interleukin-1ß, interleukin-2 and interleukin-14) in Acetamiprid rats group compared with their corresponding control group. When Acetamiprid rats group was treated with ginseng, green tea and cinnamon or/and mixture a considerable amelioration effects in all previously studied parameters were pronounced dependent on certain mechanisms and time of treatment.