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Prophylactic and Antidiabetic Effect of Andrographis paniculata and its Combination with Allium sativum on Blood Glucose Level and some Biochemical Indices in Wistar Rats

Okwuenu Gift Nonso, Igbokwe Gabriel Ejike, Ezenwelu Chijioke Obinna

Journal of Advances in Medical and Pharmaceutical Sciences · pp. 13–26 · Published 19 Aug 2023

10.9734/jamps/2023/v25i7627

Abstract

Diabetes Mellitus is a chronic health problem with devastating effect that is characterized by high blood glucose levels resulting from faults or flaws in insulin production or action. The unaffordability and adverse effects of conventional drugs in the treatment and management of many diseases has spurred the interest of scientists to the use of herbal medicine to treat and manage many ailments. The purpose of this study was to investigate the prophylactic and anti-diabetic effects of Andrographis paniculata and its combination with Allium sativum on the blood glucose level and on some biochemical indices of wistar rats. The bodyweight, fasting blood glucose level, lipid profile and lipid peroxidation were determined using standard biochemical methods. All the treatment groups indicated gradual increase in their body weights which was not above normal control and significant reduction in fasting blood glucose level was also observed in all groups but with far greater reduction seen in the pretreated groups with a percentage reduction of 61.25%. The result of the lipid profile showed that varying doses of A. paniculata and A. sativum significantly reduced the LDL, TCHOL, TRIG and VLDL levels of diabetic rats. However, the pretreatment of A. paniculata gave a higher reduction in the LDL, TCHOL, TRIG and VLDL levels. The MDA level of all the test groups decreased when compared to the diabetic untreated group and the standard drug group with significant (p< 0.05) reduction seen in the groups treated with 100mg/kg and 200mg/kg of A. paniculata. The findings from this research showed that Andrographis paniculata has the potential to be used as a remedy for the treatment and management of diabetes mellitus and its complications, however pretreatment with A. paniculata is highly recommended as it gives better results in reducing the complications associated with diabetes mellitus.

Andrographis paniculata Allium sativum bodyweight diabetes mellitus fasting blood glucose lipid peroxidation lipid profile pretreatment

References (26)

  1. 1 Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge [DOI]
  2. 2 [30] Microsomal lipid peroxidation [DOI]
  3. 3 Determination of Glucose in Blood Using Glucose Oxidase with an Alternative Oxygen Acceptor [DOI]
  4. 4 A new approach to practical acute toxicity testing [DOI]
  5. 5 The burden and costs of chronic diseases in low-income and middle-income countries [DOI]
  6. 6 Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats [DOI]
  7. 7 Garlic and Cardiovascular Disease: A Critical Review [DOI]
  8. 8 Andrographis paniculata: a review of pharmacological activities and clinical effects.
  9. 9 Potential therapeutic effects of functionally active compounds isolated from garlic [DOI]
  10. 10 Antidiabetic and antihiperlipidemic effect of Andrographis paniculata (Burm. f.) Nees and andrographolide in high-fructose-fat-fed rats [DOI]
  11. 11 A bitter plant with a sweet future? A comprehensive review of an oriental medicinal plant: Andrographis paniculata [DOI]
  12. 12 Saponins and their potential role in diabetes mellitus
  13. 13 An overview of the antifungal properties of allicin and its breakdown products – the possibility of a safe and effective antifungal prophylactic [DOI]
  14. 14 Preparing nurses to face the pandemic of diabetes mellitus: a literature review [DOI]
  15. 15 Hypolipidemic Effects of Andrographolide and Neoandrographolide in Mice and Rats [DOI]
  16. 16 GARLIC: A PUNGENT WONDER FROM NATURE [DOI]
  17. 17 Traditional Uses, Phytochemistry and Pharmacological Properties of Garlic (Allium Sativum) and its Biological Active Compounds [DOI]
  18. 18 Garlic: A spice with wide medicinal actions
  19. 19 Histopathological changes in diabetic kidney disease [DOI]
  20. 20 Hypolipidemic Effects of Coenzyme Q10 in Experimentally Induced Hypercholesterolemic Model in Female Rats [DOI]
  21. 21 Effect of Spermine, Epibrassinolid and their interaction on inflorescence buds and fruits abscission of pistachio tree (Pistacia vera L.), “Ahmad–Aghai” cultivar [DOI]
  22. 22 Effect of Chard (Beta vulgaris L. var. cicla) on Blood Glucose Levels in Normal and Alloxan‐induced Diabetic Rabbits [DOI]
  23. 23 Diabetes: A Silent Killer in Nigeria [DOI]
  24. 24 Biochemical Aspects of Diabetes Mellitus [DOI]
  25. 25 International Research Journal Of Pharmacy [DOI]
  26. 26 The effect of salinity stress on the morpho-physiology and protein profile of andrographis paniculata

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