Proliferative Verrucous Leukoplakia: A Diagnostic Perplexity
Nidhi Sinha, Meghanand T. Nayak, Shreya Gupta, Devangi Dwivedi, Neeti Swarup, Mansi Agarwal
International Journal of Research and Reports in Dentistry · pp. 149–154 · Published 4 Aug 2021
Abstract
Proliferative verrucous leukoplakia (PVL) is an uncommon pathological lesion which is defined as a diffuse, white and smooth or papillary or wart-like exophytic growth of oral mucosa showing capricious degrees of epithelial hyperplasia. Initially, the lesion shows focal clinical hyperkeratosis that gradually becomes a comprehensive multifocal disease. In its primary stages, the lesion clinically is bland that it is often diagnosed as frictional hyperkeratosis or hyperplastic candidiasis, but with its descriptive natural features of chronic proliferation, copious occurrences, refractoriness to treatment and high rate of malignant transformation, it can be positively diagnosed as oral proliferative verrucous leukoplakia (OPVL).
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