Prevalence of Down Syndrome in Western India: A Cytogenetic Study
Gadhia Pankaj, Kathiriya Avani, Vaniawala Salil
Journal of Advances in Medicine and Medical Research · pp. 1255–1259 · Published 5 Nov 2014
10.9734/BJMMR/2015/13648Abstract
Aim: To study the prevalence of Down syndrome by conventional chromosome analysis and G-banded karyotyping. Materials and Methods: A retrospective analysis was performed on the case records of2750 paediatrics patients, of which 682 cases of confirmed Down syndrome was recorded by G-banding karyotyping. Results: Non-disjunction was the most common type of abnormality followed by Robertsonian translocation and lastly mosaic in ratio of 92.2:7.0:0.73 respectively. Conclusion: Results suggest that advanced maternal age is classic risk factor attributed to the incidences of Down syndrome.
References (8)
- 1 A RAPID BANDING TECHNIQUE FOR HUMAN CHROMOSOMES [DOI]
- 2 The Influence of Paternal Age on Down Syndrome [DOI]
- 3 Chromosomal Abnormalities: Genetic Disease Burden in India [DOI]
- 4 Cytogenetic and clinical profile of Down syndrome in Northeast Malaysia.
- 5 Cytogenetic Evaluation of Down Syndrome: A Review of 1020 Referral Cases [DOI]
- 6 The MTRR 66A>G polymorphism and maternal risk of birth of a child with Down syndrome in Caucasian women: a case–control study and a meta-analysis [DOI]
- 7 Cytogenetic analysis of Down syndrome in Gujarat.
- 8 A study of new potential risk factors for Down syndrome in Upper Egypt [DOI]
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