Skip to content
Research Article Open access CC BY 4.0

Preliminary Investigation of the Renal Toxicity of Monosodium Glutamate in Rats Determined by Some Serum Biochemical Markers

H. O. Akanya, I. F. Ossamulu, F. S. Adefolalu, A. V. Oloniyi

Journal of Advances in Medical and Pharmaceutical Sciences · pp. 1–8 · Published 11 Dec 2015

10.9734/JAMPS/2016/19825

Abstract

The potential renal toxicity of monosodium glutamate (MSG) following dietary administration for four weeks in Albino rats was preliminary investigated by the measurement of serum electrolytes, urea and creatinine levels. The rats were randomly divided into four (4) groups based on the proportion of MSG supplemented in their diets. Group A was fed with commercial chow (control) while groups B, C and D were placed on 0.5, 1.0 and 5.0% MSG supplemented diets respectively. The serum electrolytes, urea and creatinine were analyzed using TECO Diagnostic kits. The sodium and chloride concentrations in the experimental groups were not significantly (p > 0.05) different from the control group. Group fed 5% MSG supplemented diet had the highest potassium concentration (6.00±0.83 Mmol/L) while the group placed on 0.5% MSG supplemented diet had the lowest concentration (4.68±0.16 Mmol/L). There was a significant (p < 0.05) difference in the potassium ion concentration between the experimental groups and the control group. The urea concentration ranged from 6.28±0.10 Mmol/L to 7.13±0.36 Mmol/L in the experimental groups whereas the creatinine concentration ranged from 1.38±0.48mmol/L to 1.4±0.11 Mmol/L. The urea concentration of rats in the experimental groups were significantly (p < 0.05) lower than the control group. The creatinine concentration of rats in the experimental groups were not significantly different (p > 0.05) from those in the control group. This work has shown that high supplementation of diet with MSG could induce hyperkalemia and hypouremia in rats.  

Monosodium Glutamate (MSG) electrolytes urea creatinine supplemented diet

References (16)

  1. 1 Tietz Textbook of Clinical Chemistry [DOI]
  2. 2 Clinical Guide to Laboratory Tests. [DOI]
  3. 3 Serum Potassium and Outcomes in CKD [DOI]
  4. 4 Consumption of monosodium glutamate in relation to incidence of overweight in Chinese adults: China Health and Nutrition Survey (CHNS) [DOI]
  5. 5 Hyperkalemia in Dialysis Patients [DOI]
  6. 6 Effects of added glutamate on liking for novel food flavors [DOI]
  7. 7 [Disorders of potassium metabolism I].
  8. 8 Obesity and changes of alkaline phosphatase activity in the small intestine of 40- and 80-day-old rats subjected to early postnatal overfeeding or monosodium glutamate. [DOI]
  9. 9 Protective effect of Piper longum Linn. on monosodium glutamate induced oxidative stress in rats.
  10. 10 Study on evaluation of monosodium glutamate induced oxidative damage on renal tissue on adult wistar rats.
  11. 11 Determination of Nephrotoxicity and Hepatoxicity of Monosodium Glutamate (MSG) Consumption
  12. 12 Parathyroid Hormone Interferes with Extrarenal Disposition of Potassium in Chronic Renal Failure [DOI]
  13. 13 HISTOLOGICAL STUDIES OF THE EFFECTS OF MONOSODIUM GLUTAMATE ON THE SMALL INTESTINE OF ADULT WISTAR RATS.
  14. 14 Relationship between parathyroid hormone and electrolytes in chronic kidney disease
  15. 15 Influence of sub-chronic oral exposure to high monosodium glutamate on some serum markers of the renal functions in male Wistar rats [DOI]
  16. 16 Evaluation of MSG on Electrolyte Balance and Histology of Gastroesophageal Mucosa

Cited by 1

Renal-Biofunction Potentials of Ethanolic Extract of Solanum Melongena Linn Fruit on Monosodium Glutamate- Intoxicated Rats and Kidney Histology

U. Mbah, Ijere D. Nwanne, O. Jeremiah · Journal of Diagnostics · 2019

Related research

Article metrics

Real usage data collected on this platform.

67

Page views

0

PDF downloads

27

Outbound clicks

1

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.