Preclinical Appraisal of Hematinic Potential of Mandura Bhasma for Treating Anemia
Deepak S. Khobragade, Mrunali S. Potbhare, Awdhut Pimpale, Sagar B. Wankhede, Chandrashekhar R. Tempe
Journal of Pharmaceutical Research International · pp. 207–214 · Published 7 Jun 2021
10.9734/jpri/2021/v33i30B31656Abstract
Aims: To evaluate hematinic potential of mandura bhasma. Study Design: Experimental study. Place and Duration of Study: Institute of Pharmaceutical Education and Research, Wardha, Maharashtra, India. 6 Months. Methodology: The anti-anaemic potential of Mandura bhasma in Wistar rats was investigated. Anaemia was induced in rats with phenyl hydrazine hydrochloride at a dose of 10 mg kg-1 body weight by oral administration. Anaemia was treated with mandura bhasma administered in three different doses based on body weight. Results: In vivo investigation showed that though the dose of 6mg kg-1 body weight of mandura bhasm produced only a minimal antianaemic (hematinic) effect, oral daily dose of 11 mg kg-1 body weight and 22mg kg-1 body weight a produced a significant (P < 0.05) antianaemic effect when compared to standard drug ferrous sulphate indicating dose dependent activity. Conclusions: The results indicate that Mandura Bhasm have very potential dose dependant hematinic activity and can be a safe and effective drug for treating anemia.
Cited by 3
Jitendra Patel, H. Roy, Deepak S. Khobragade · Research Journal of Pharmacy and Technology · 2025
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