Impact of Different Chemically Synthesized Silver Nanoparticles on Nosocomial Infection

Abstract

Aim: Nosocomial infection (NI), or so-called hospital-acquired infection, is one of the most important problems facing us and the world at this time. This study aims to investigate the effect of minimum inhibition concentration of Ag-NPs on isolated bacteria from nosocomial infections. Place and Duration of Study: Gastroenterology Surgical Center, Mansoura University, Mansoura, Egypt, between July 2017 and July 2018. Methodology: A total of 368 different samples of 100 patients were taken which staying for 3 days or more in Gastroenterology Surgical Center, Mansoura University, Egypt. Three different types of Ag-NPs ‎synthesized by three different chemical methods were used. Results: The results showed that the highest rate of infection of NI was found in K. Pneumoniae with an estimated percentage of 40%. The size of spherical Citrated-Ag-NPs ‎‎ was found in the range of 15-57 nm. On the contrary, the size of spherical Polyvinyl-Pyrrolidone (PVP) and PVP Glucose Ag-NPs were found to be smaller with size ranging from 7.8-23 and 7.58-25 nm, respectively.  Conclusion: Our findings showed that PVP Glucose Ag-NPs had the highest impact on all types of isolated bacteria associated with nosocomial infections.