Potency of Phytochemicals from Guava (Psidium guajava) Seeds against Escherichia coli to Cure Diarrhoea: An in silico Analysis
Barsha Nayak, Lopita Mishra, Bibhu Prasad Mishra, Srimay Pradhan, Bhagyeswari Behera, Mukundjee Pandey
Journal of Pharmaceutical Research International · pp. 110–113 · Published 21 Jun 2020
10.9734/jpri/2020/v32i930538Abstract
Machine learning to deep learning is the enduring upgrading in the pharmaceutical research field. Phytochemicals from Psidium guajava plant extract are traditionally used to cure Diarrhoea. The causative agent of the disease is Escherichia coli. To identify the secondary metabolites (ligand) which is the main responsive compound that have the capacity to inhibit the growth of microorganism was carried by molecular docking method “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that Heptadecanoic acid can effectively deactivate the shikimate dehydrogenase enzyme thereby interrupting the life cycle of the organism.
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