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Research Article Open access CC BY 4.0

Positive Stimulatory Potentials of Coconut (Cocos nucifera L.) Juice Extract on in vivo Antioxidants, Renal Function and Lipid Profile of Male Wistar Rats

E. D. Kpomah, E. M. Arhoghro

European Journal of Medicinal Plants · pp. 45–54 · Published 8 Apr 2023

10.9734/ejmp/2023/v34i31129

Abstract

Coconut juice is a natural drink from coconut fruit. This study was aimed at evaluating its positive potential on biochemical indices. Fresh coconut fruits were de-dshelled and washed. The cotyledon was broken to extract the water which was used in blending the fruits. The extract was filtered and the filtrate was collected in a vial. Twenty healthy male Wistar rats weighing 160 -180 g, were grouped into two groups of ten rats each and were treated as follows for four weeks. Group A: control rats received oral dose of 2 mL/kg body weight of distilled water once daily for 28 days, and group B: received oral dose of 2 mL/kg body weight of coconut juice extract once daily for 28 days, both groups were, however, allowed free access to feed and water ad-libitum. The animals were weighed before and on completion of the experimental protocol. Blood was also collected via cardiac puncture and used for renal function and lipid profile assay, kidneys were excised and weighed, homogenized and the supernatant was used for antioxidant enzyme evaluation. Findings showed that there was no significant change (p>0.05) in the kidney-to-body weight ratio and renal function indices. Significant reduction (p<0.05) was seen in cholesterol, triglycerides, LDL but with an increase (p<0.05) in HDL. Antioxidant enzymes were significantly increased (p<0.05). The study concludes that coconut juice extract has positive stimulatory potentials on antioxidants, renal functions and lipid parameters of wistar rats.

Coconut juice extract antioxidants lipid profile renal function

References (41)

  1. 1 Glutathione S-Transferases [DOI]
  2. 2 The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase [DOI]
  3. 3 Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions [DOI]
  4. 4 Measurement of catalase activity in tissue extracts [DOI]
  5. 5 GLUTATHIONE S-TRANSFERASES: GENE STRUCTURE, REGULATION, AND BIOLOGICAL FUNCTION [DOI]
  6. 6 Novel antioxidants in food quality preservation and health promotion [DOI]
  7. 7 Oxidative stress and antioxidant mechanisms in human body [DOI]
  8. 8 Relationships between tissue concentrations of polycyclic aromatic hydrocarbons and antioxidative responses of marine mussels, Perna viridis [DOI]
  9. 9 Dyslipidemia and cardiovascular disease risk among the MASHAD study population [DOI]
  10. 10 Antioxidant and biochemical properties of protein hydrolysates prepared from Silver carp (Hypophthalmichthys molitrix) [DOI]
  11. 11 Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review [DOI]
  12. 12 Effect of reagent pH on determination of high-density lipoprotein cholesterol by precipitation with sodium phosphotungstate-magnesium. [DOI]
  13. 13 Medical Laboratory Science: Theory and Practice
  14. 14 Simplified enzymic/colorimetric serum urea nitrogen determination. [DOI]
  15. 15 Biomarkers and Mechanisms of Oxidative Stress—Last 20 Years of Research with an Emphasis on Kidney Damage and Renal Transplantation [DOI]
  16. 16 Determining organ weight toxicity with Bayesian causal models: Improving on the analysis of relative organ weights [DOI]
  17. 17 Association between dietary patterns, cadmium intake and chronic kidney disease among adults [DOI]
  18. 18 Evaluation of acute and subchronic toxicity of Annona muricata (Linn.) aqueous extract in animals
  19. 19 Comparative Effectiveness of Personalized Lifestyle Management Strategies for Cardiovascular Disease Risk Reduction [DOI]
  20. 20 Molecular mechanisms underlying the anti-obesity potential of prunetin, an O-methylated isoflavone [DOI]
  21. 21 Prevention of Nephropathy by Some Natural Sources of Antioxidants [DOI]
  22. 22 Dietary coconut water vinegar for improvement of obesity-associated inflammation in high-fat-diet-treated mice [DOI]
  23. 23 Coconut water vinegar ameliorates recovery of acetaminophen induced liver damage in mice [DOI]
  24. 24 Catalase evaluation in different human diseases associated with oxidative stress.
  25. 25 Curative Potential of Aqueous Extract of Lemon Grass (Cymbopogon Citratus) on Cisplatin Induced Hepatotoxicity in Albino Wistar Rats
  26. 26 The important role of apolipoprotein A-II in ezetimibe driven reduction of high cholesterol diet-induced atherosclerosis [DOI]
  27. 27 Antioxidant Property and Cardiovascular Effects of Coconut (Cocos nucifera) Water [DOI]
  28. 28 Antioxidant and Cardioprotective Effect of Coconut Water against Doxorubicin Induced Cardiomyopathy
  29. 29 Studies on the Composition and In-Vitro Antioxidant Activities of Concentrates from Coconut Testa and Tender Coconut Water [DOI]
  30. 30 Assessment of Kidney Function Indices in Male Albino Wistar Rats Administered Ethanol Stem Extract of Dennettia tripetala (Pepper fruit) [DOI]
  31. 31 A candidate reference method for uric acid in serum. II. Interlaboratory testing. [DOI]
  32. 32 Analgesic, Non-ulcerogenic and Antioxidant Activities of the Aqueous Stem Bark Extract of Morinda lucida (Rubiaceae) in Mice [DOI]
  33. 33 Alternative fruit and vegetables consumption for 1-3 year old Indonesian children [DOI]
  34. 34 Can I have Tender Coconut Water Daily? [DOI]
  35. 35 Effects of doses of Bryophylum pinnatum and glibenclamide on serum glucose and lipid profile in alloxan-induced diabetic rats
  36. 36 Beneficial effects of young coconut juice feeding on the lipid,renal and liver profiles, in ovariectomized rats: Preliminary novel findings [DOI]
  37. 37 International Journal of Pharmaceutical Sciences and Research [DOI]
  38. 38 Brazilian Journal of Medical and Biological Research 1981-2002 [DOI]
  39. 39 IOSR Journal of Environmental Science Toxicology and Food Technology [DOI]
  40. 40 Journal of Applied Life Sciences International [DOI]
  41. 41 Aging, Metabolic, and Degenerative Disorders: Biomedical Value of Antioxidants [DOI]

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