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Research Article Open access CC BY 4.0

Polar Diels-Alder Reactions Using Heterocycles as Electrophiles. Influence of Microwave Irradiation

María N. Kneeteman, Anna F. López Baena, Claudia Della Rosa, Pedro M. E. Mancini

International Research Journal of Pure and Applied Chemistry · pp. 229–235 · Published 4 Jun 2015

10.9734/IRJPAC/2015/18867

Abstract

In this work we studied a series of polar Diels-Alder reactions using different heterocycles derivatives acting as electrophiles joint to dienes of different nucleophilicity, analyzing the effect of the microwave irradiation in these processes. We employ the technique in two conditions: benzene as solvent and solvent free reactions. The last one presents the better yield in shorter time of reaction. Using microwave heating the aromatic cycloadducts are clearly predominant. It is possible to demonstrate that the microwave irradiation has a better influence on these cycloaddition reactions respect to those developed in thermal classical conditions.  

Aromatic heterocycles electrophiles microwave irradiation solvent free Diels-Alder

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Cited by 13

Polar Diels-Alder Reactions Under Microwave Irradiation Employing Different Heterocyclic Compounds as Electrophiles

Pedro M.E. Mancini, Carla M. Ormachea, María N. Kneeteman · Mini-Reviews in Organic Chemistry · 2019

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