Antibiotic Susceptibility Patterns and Bacteriological Profile of Catheter-Associated Urinary Tract Infections in a Tertiary Care Hospital in Bangladesh: A Cross-Sectional Study

Abstract

Aim and Objective: This study aimed to analyze the bacteriological profile of catheter-associated urinary tract infections (CAUTI) and their antibiotic susceptibility patterns in a tertiary care hospital in Bangladesh to inform appropriate treatment guidelines and help reduce the development of multi-drug resistance among organisms. Materials and Methods: A cross-sectional study was conducted from June 2021 to December 2022, involving 694 urine samples from catheterized patients. Samples were processed and inoculated on Cystine Lactose Electrolyte Deficient (CLED) agar, and bacterial etiological agents were identified. Antibiotic susceptibility testing was performed using the Modified Kirby-Bauer Disk Diffusion method, following Clinical and Laboratory Standards Institute (CLSI) 2022 - M100 guidelines. Results: The study found varying susceptibility patterns across different antibiotic classes, with higher resistance rates for Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli compared to some previous research. Amikacin showed the highest susceptibility rate among aminoglycosides (31.2%), while colistin had the highest susceptibility rate in the polymyxin class (85.7%). Organism-wise susceptibility patterns indicated statistically significant differences in resistance patterns for Pseudomonas aeruginosa and Escherichia coli across various antibiotic classes. Conclusion: Our findings underscore the urgent need for continuous surveillance and monitoring of antibiotic resistance patterns and the development of new strategies to combat antibiotic-resistant bacteria. The data provided in this study will aid clinicians in selecting appropriate antimicrobial therapy for catheter-associated urinary tract infections caused by the isolated pathogens, ultimately contributing to the reduction of multi-drug resistance among organisms.