Synthesis and Anti-Breast Cancer Activity of Some New Organoselenium Compounds

Abstract

A series of selenazole, (selenazol-nitrone) and selenazine derivatives were synthesized. The reaction of arylselenocarboxamides with substituted α-halo carbonyl compounds, such as 3-chlorobutan-2-one, 1-chloropropan-2-one, 2-bromomalonaldehyde and 2-chloroacetyl chloride, afforded four cyclic compounds of substituted 2-aryl-1, 3-selenazole, while the reaction of aryl seleno carboxamides with substituted β-halo carbonyl compounds, such as 3-chloro-1-(4-chlorophenyl) propan-1-one and 3-chloro-1-phenylpropan-1-one, afforded two cyclic compounds of substituted 2-aryl-1, 3-selenazines. The reaction between 2-phenyl-1, 3-selenazole-5-carbaldehyde and N-4-fluorophenyl hydroxylamine afforded a compound of selenazole combined with nitrone. All synthesized compounds were characterized by FTIR, 1H NMR, 13C NMR and MASS spectroscopy. The results verified the expected chemical structures of synthesized compounds. MTT assay used to evaluate 1, 3-selenazine (S6), namely 2, 4-diphenyl-6H-1, 3-selenazine against human breast cancer MDA-MB231 with 24 and 48 h. Thus, compound S6 showed significant activity against breast cancer.