Comparative Analysis of Matriderm and Biodegradable Temporizing Matrix in Full-thickness Burn and Post-traumatic Wound Management: A Single-institution Study

Abstract

Background: Wound management has advanced significantly with the introduction of dermal substitutes, offering improved healing outcomes and patient care. This study evaluates the effectiveness and integration of two dermal substitutes — Matriderm and Biodegradable Temporizing Matrix (BTM) — in the management of full-thickness burns and post-traumatic wounds. Methods: This institutional study included 14 patients with full-thickness burns or post-traumatic wounds, divided into two groups of seven each. Matriderm and BTM were applied following standard wound bed preparation procedures, and grafting was performed after 15-21 days. Primary outcomes measured were integration with host tissue, infection rates, time to complete wound healing, and scar quality. Secondary outcomes included cost-effectiveness, patient satisfaction and adverse reactions. Results: Both Matriderm and BTM showed similar integration rates with host tissue and comparable healing times. Infection rates were equivalent between the groups. Matriderm resulted in superior scar quality, leading to higher patient satisfaction. BTM demonstrated greater cost-effectiveness, making it an attractive option from an institutional perspective. Conclusion: Matriderm and BTM are both effective in managing complex wounds. Matriderm excels in providing superior scar quality, while BTM offers significant cost advantages. The integration of these dermal substitutes into clinical practice enhances wound care outcomes, emphasizing the importance of tailored approaches based on individual patient needs and specific wound characteristics.