Skip to content
Research Article Open access CC BY 4.0

Pharmacognostic Evaluation and Hepatoprotective Property of Crude and Fractions of Triumfetta cordifolia A. Rich. (Tiliaceae)

Chikeokwu Ikenna, Ene Erica Chiamaka, C. Mba Theodora, Uche Estella Odoh

Journal of Advances in Medical and Pharmaceutical Sciences · pp. 1–9 · Published 21 Apr 2023

10.9734/jamps/2023/v25i3603

Abstract

Background: The role of phytochemicals in modern medicine is abundant with more evidence being published. Triumfetta cordifolia is a local plant known for its vast medicinal applications in traditional medicine with limited documented evidence. This study thus aims to evaluate the leaves of Triumfetta cordifolia to determine its Pharmacognostic parameters and  hepatoprotective potential. Methodology: The leaves were collected, identified, dried and subsequently pulverized before maceration in methanol. This was followed by fractionation using different solvent with increasing polarities (n-hexane, n-butanol, ethyl acetate and aqueous methanol). Physicochemical evaluations such as macroscopy, organoleptic tests, qualitative phytochemical analysis and total phenolic content was subsequently conducted on the extracts. Finally, an acute toxicity test and hepatoprotective evaluation was performed, the latter using carbon tetrachloride. Results: The leaves Triumfetta cordifolia on macroscopic evaluation  shown a simple, alternate, stipules triangular, densely stellate hairy leaves. The organoleptic evaluation indicated a pungent aromatic smell and a slightly bitter taste. Several phytochemicals such as tannins, saponins, glycosides, steroids and flavonoids were identified qualitatively.The extracts was safe at a dose less than 5,000mg/kg. The ethyl acetate fraction showed consistent hepatoprotective activity at a concentration of 400 mg/kg when compared to Gallic acid (positive control). This was possibly due to its high composition of phenolic compounds which was recorded during the study. Conclusion: The ethyl acetate fraction of  Triumfetta cordifolia leaves exhibited a hepatoprotective effect thus showcasing the potential benefits of the plant in mitigating liver damage. More research is however needed to identify specific compounds being extracted that may be responsible for the activity recorded in this study.

Triumfetta cordifolia hepatoprotective phytochemical ethyl acetate pharmacognostic

References (17)

  1. 1 A new approach to practical acute toxicity testing [DOI]
  2. 2 Medicinal Plants and Traditional Medicine in Africa [DOI]
  3. 3 Quantification of Polyphenolics and Their Antioxidant Capacity in Fresh Plums [DOI]
  4. 4 Factors influencing levels of phytochemicals in selected fruit and vegetables during pre- and post-harvest food processing operations [DOI]
  5. 5 Measurement of total phenolic content and antioxidant activity of aerial parts of medicinal plant Coronopus didymus [DOI]
  6. 6 Evaluation of antioxidant activity and total phenol in different varieties of Lantana camara leaves [DOI]
  7. 7 Acetaminophen Toxicity: Novel Insights Into Mechanisms and Future Perspectives [DOI]
  8. 8 Determination of total phenolic content and antioxidant activity of Commiphora mollis (Oliv.) Engl. resin [DOI]
  9. 9 Drug‐Induced Liver Injury: The Role of Drug Metabolism and Transport [DOI]
  10. 10 Drug-induced liver injury: present and future [DOI]
  11. 11 The role of liver in metabolism: an updated review with physiological emphasis [DOI]
  12. 12 Methylation protects dietary flavonoids from rapid hepatic metabolism [DOI]
  13. 13 Medicinal plants with hepatoprotective potentials against carbon tetrachloride-induced toxicity: a review [DOI]
  14. 14 Chemical Composition, Hepatoprotective and Antioxidant Activity of the Crude Extract and Fractions of the Leaves of Fadogia Cienkowskii Schweinf (Rubiaceae) [DOI]
  15. 15 Drug-Induced Hepatotoxicity [DOI]
  16. 16 Pharmacognostic Evaluation and Anti-Diabetic Activity of Ethanol Extract of Triumfetta cordifolia A. Rich (Tiliaceae) Leaves [DOI]
  17. 17 Phytochemical methods—a guide to modern techniques of plant analysis [DOI]

Cited by 0

No indexed citations yet.

Related research

Article metrics

Real usage data collected on this platform.

2

Page views

0

PDF downloads

0

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.