Solvothermal Synthesis, Characterization and Cytotoxicity Study of Cobalt and Copper of Complexes Sulfamethoxazole
Usman Abubakar Adamu, Buhari Magaji, Adamu Baba Mohammad, Mukhtar Muhammad Sani, Zulaihat Isa Hussaini
Asian Journal of Physical and Chemical Sciences · pp. 6–12 · Published 7 May 2020
10.9734/ajopacs/2020/v8i230111Abstract
The complexes of Co and Cu with sulfamethoxazole (SMZ) were synthesized in the 1:2 molar ratios. The physical characterization of the ligand and the complexes showed different colours with a good % yield and high melting point/decomposition temperature. The solubility test of the metal complexes and the free drug using various solvents of different polarity and proticity showed that the free drug and the metal complexes are soluble in polar and non-polar solvents. The IR results of the synthesized complexes displayed new peaks that are not present in the free drug, the bands are due to M-O and M-N thus, confirming the coordination. The result from the conductivity measurement shows that the complexes are non-electrolyte. More so, all the complexes were found to be toxic in brine shrimp lethality assay.
Cited by 1
U. Adamu, B. Magaji, A. Mohammad · 2020
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