Novel Routes to Biologically Active Enaminones, Dienoic Acid Amides, Arylazonicotinates and Dihydropyridazines under Microwave Irradiation
M. A. El-Apasery, S. M. Al-Mousawi, H. Mahmoud, M. H. Elnagdi
International Research Journal of Pure and Applied Chemistry · pp. 69–83 · Published 24 Aug 2011
10.9734/IRJPAC/2011/504Abstract
Condensation of methylketones 1a,b with dimethylformamide dimethyl acetal (DMFDMA) without solvent in microwave oven afforded enaminones 2a,b, which reacted with malononitrile in ethanolic piperidine to yield dienoic acid amides 7a,b. In contrast, reactions of 2a,b with cyanoacetic acid resulted in the formation of pyranones 10. The pyranones were readily converted into 2-arylhydrazonoketones 13. Condensations of 13 with ethyl cyanoacetate afforded the 5-arylazonicotinates 17. Finally, 2-oxoarylhydrazonals 18 reacted with arylidenemalononitriles 19a,b in presence of chitosan to afford dihydropyridazines 21a,b. In addition the biological activity of the title compounds against Gram positive bacteria, Gram negative bacteria and Yeast were also evaluated.
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Cited by 34
Saleh M. Al-Mousawi, Morsy A. El-Apasery · Molecules · 2012
Saleh Mohammed Al-Mousawi, Morsy Ahmed El-Apasery, Mohamed Hilmy Elnagdi · European Journal of Chemistry · 2014
Alya M. Al-Etaibi, Morsy A. El-Apasery, Huda M. Mahmoud · Molecules · 2012
E.M. El-Menyawy, A.A. Elagamey, S.R. Elgogary · Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy · 2013
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Megan L. Elliott, Kevin Thomas, Steven Kennedy · Chemical Biology & Drug Design · 2015
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Refat El‐Sayed · Journal of Surfactants and Detergents · 2016
Morsy Ahmed El-Apasery, Fawzia Al-Qalaf, Khaledah Almohammad · European Journal of Chemistry · 2013
Nouria A. Al-Awadi, Yehia A. Ibrahim, M.H. Elnagdi · Journal of Analytical and Applied Pyrolysis · 2017
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