Novel Organo Phosphonate-1,2,3 Triazole Derivatives: Molecular Properties Prediction
Jhonsee Rani Telu, Naveen Kuntala, Jaya Shree Anireddy, Sarbani Pal
Chemical Science International Journal · pp. 1–7 · Published 31 Dec 2020
10.9734/CSJI/2020/v29i1030206Abstract
In the present scenario drug discovery and development processes are expensive and time consuming. To resolve this, we utilised the Lipinski’s rule (Ro5) methodology, which appears to be useful in defining drugability. In the present investigation, we reported the synthesis and evolution of antibacterial activity of title compounds and according to Rule of 5 series, twenty novel ((R)-dimethyl (hydroxy(4-((1-(2-nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)methyl)phosphonate-1,2,3-triazole derivatives were subjected to molecular properties prediction, drug likeness by Molinspiration (Molinspiration, 2020) and Molsoft (Molsoft, 2020) software.
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