Normal Reference Range for Serum TSH, Free T4, Total T4, and Total T3 on Roche® Platforms in Basrah, Iraq
Nassar Taha Alibrahim, Samih Abed Odhaib, Ali Hussain Alhamza, Ammar Mohammed Saeed Almomin, Ibrahim Abbood Zaboon, Rudha Naser Hussein, Muayad Baheer Kadhim, Adel Gassab Mohammed, Dheyaa Kadhim Al-Waeli, Hussein Ali Nwayyir, Haider Ayad Alidrisi, Ibrahim Hani Hussein, Mahmood Thamer Altemimi, Husam Jihad Imran, Abbas Ali Mansour
Journal of Pharmaceutical Research International · pp. 147–155 · Published 29 Sep 2021
10.9734/jpri/2021/v33i45A32727Abstract
Background: Thyroid function tests are mandatory in clinical practice because symptoms and signs are not reliable to discriminate between various types of thyroid disease. Aim: The aim of this study was to determine assay-specific reference range for serum free T4, total T4, total T3 and TSH among healthy non-pregnant adult cohort for Roche® platforms in Basrah (Southern Iraq) from single laboratory in a tertiary center using indirect approach of the available data. Methods: A Cross sectional study for non-pregnant adults 19 years and above. Sera were analyzed by using cobs e411 for thyroid functions tests. Results: Total enrolled persons were 10,078. The 95% reference intervals for TSH were 0.20-6.50 μIU/mL, which increased with age though not linear, for free T4 were 0.8-1.70 ng/dL, for total T4 were 3.78-15.33 μg/dL, and for total T3 were 0.80-2.50 ng/mL. Colcusion: Cobs e411(Roche® analytical platform) analyzer reference range for thyroid function cannot be applied for Iraqi population .
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