Neuroprotective Effect of Nilotinib on Cortical Pyramidal Cells, Histological, Morphometric and Biochemical Study
Annual Research & Review in Biology · pp. 23–33 · Published 1 May 2020
10.9734/arrb/2020/v35i330197Abstract
Introduction: Death of neuronal cell and gliosis are the two main pathological hallmarks induced by nervous tissue stress like conditions such as status epilepticus. Previous studies have mentioned that neuronal cell death occur as a result of different mechanisms, namely, necrosis and apoptosis. Although more recent studies have explained the cell death on the basis of autophagy. Many antiepileptic drugs are marketed, taking into consideration the antioxidant role of nilotinib and support its use as a favorable antiepileptic drug. The aim of the present study is to assess the neuroprotective effect of antiepileptic drug nilotinib on cortical tissue in rats. Materials and Methods: Sixty adult male rats were divided into three groups: (1) Control group, (2) pentylenetetrazol group (injected with pentylenetetrazol 60 mg/kg, subcutaneously), (3) nilotinib and pentylenetetrazol group (pretreated with nilotinib, 25 mg/kg daily for seven days prior to pentylenetetrazol administration). Latency of seizure and level of either oxidant or antioxidant enzymes in the cortical tissue was assessed. The histopathological changes in the cerebral cortex were studied also using hematoxylin and eosin stain. Results: Nilotinib increased the latency period of convulsions, increased the antioxidant enzymes levels with regain of the normal histological features. Conclusions: Nilotinib proved to promote the antioxidant, antiapoptotic pathways, anti-inflammatory and inhibiting autophagy which favor its use as an anti-epileptic drug.
References (63)
- 1 Theory and Practice of Histological Techniques
- 2 Nitric oxide synthases: regulation and function [DOI]
- 3 The Beclin 1 network regulates autophagy and apoptosis [DOI]
- 4 Nrf2–Keap1 defines a physiologically important stress response mechanism [DOI]
- 5 Structural Basis for Defects of Keap1 Activity Provoked by Its Point Mutations in Lung Cancer [DOI]
- 6 A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders [DOI]
- 7 Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria [DOI]
- 8 The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy [DOI]
- 9 Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism [DOI]
- 10 Neuronal autophagy and neurodegenerative diseases [DOI]
- 11 Distribution of Brain‐Derived Neurotrophic Factor in Rats and Its Changes with Development in the Brain [DOI]
- 12 Cytokines and epilepsy [DOI]
- 13 Mitochondrial dysfunction and oxidative stress: a contributing link to acquired epilepsy? [DOI]
- 14 The c-Abl inhibitor, Nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease [DOI]
- 15 A Retrospective Analysis of Hippocampal Pathology in Human Temporal Lobe Epilepsy: Evidence for Distinctive Patient Subcategories [DOI]
- 16 When and How Do Seizures Kill Neurons, and Is Cell Death Relevant to Epileptogenesis? [DOI]
- 17 Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome [DOI]
- 18 The pilocarpine model of epilepsy: what have we learned? [DOI]
- 19 Glycogen accumulation underlies neurodegeneration and autophagy impairment in Lafora disease [DOI]
- 20 Intermediate filaments and stress [DOI]
- 21 Nrf2 Possesses a Redox-sensitive Nuclear Exporting Signal in the Neh5 Transactivation Domain [DOI]
- 22 Impaired Autophagy in Neurons after Disinhibition of Mammalian Target of Rapamycin and Its Contribution to Epileptogenesis [DOI]
- 23 Oxidative Stress and Autophagy in the Regulation of Lysosome-Dependent Neuron Death [DOI]
- 24 Induction of Autophagy by Cystatin C: A Mechanism That Protects Murine Primary Cortical Neurons and Neuronal Cell Lines [DOI]
- 25 Hippocampal gene expression dysregulation of Klotho, nuclear factor kappa B and tumor necrosis factor in temporal lobe epilepsy patients [DOI]
- 26 Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors [DOI]
- 27 Brain-Derived Neurotrophic Factor mRNA and Protein Are Targeted to Discrete Dendritic Laminas by Events That Trigger Epileptogenesis [DOI]
- 28 Role of Central Nervous System Glucagon-Like Peptide-1 Receptors in Enteric Glucose Sensing [DOI]
- 29 Persistent impairment of mitochondrial and tissue redox status during lithium‐pilocarpine‐induced epileptogenesis [DOI]
- 30 The influence of anticonvulsant and antioxidant drugs on nitric oxide level and lipid peroxidation in the rat brain during penthylenetetrazole-induced epileptiform model seizures [DOI]
- 31 Selenium and Topiramate Modulates Brain Microsomal Oxidative Stress Values, Ca2+-ATPase Activity, and EEG Records in Pentylentetrazol-Induced Seizures in Rats [DOI]
- 32 Nilotinib and bosutinib modulate pre-plaque alterations of blood immune markers and neuro-inflammation in Alzheimer’s disease models [DOI]
- 33 Comparison of imatinib, nilotinib and silymarin in the treatment of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis [DOI]
- 34 Overview of Nrf2 as Therapeutic Target in Epilepsy [DOI]
- 35 The Effects of Ascorbic Acid on Penicillin‐induced Epileptiform Activity in Rats [DOI]
- 36 Effects of a lyophilized aqueous extract of Feretia apodanthera Del. (Rubiaceae) on pentylenetetrazole-induced kindling, oxidative stress, and cognitive impairment in mice [DOI]
- 37 Can pentylenetetrazole and maximal electroshock rodent seizure models quantitatively predict antiepileptic efficacy in humans? [DOI]
- 38 Ascorbic acid ameliorates seizures and brain damage in rats through inhibiting autophagy [DOI]
- 39 Effects of Agomelatine on Oxidative Stress in the Brain of Mice After Chemically Induced Seizures [DOI]
- 40 Mammalian Target of Rapamycin (mTOR) Inhibition: Potential for Antiseizure, Antiepileptogenic, and Epileptostatic Therapy [DOI]
- 41 The Anticonvulsant Effects of SR 57227 on Pentylenetetrazole-Induced Seizure in Mice [DOI]
- 42 Gangliosides induce autophagic cell death in astrocytes [DOI]
- 43 Nilotinib ameliorates lipopolysaccharide-induced acute lung injury in rats [DOI]
- 44 Region-specific alterations of AMPA receptor phosphorylation and signaling pathways in the pilocarpine model of epilepsy [DOI]
- 45 Neuritic Outgrowth Associated with Astroglial Phenotypic Changes Induced by Antisense Glial Fibrillary Acidic Protein (GFAP) mRNA in Injured Neuron–Astrocyte Cocultures [DOI]
- 46 Consequences of nitric oxide generation in epileptic‐seizure rodent models as studied by in vivo EPR [DOI]
- 47 Oxygen seizure latency and peroxynitrite formation in mice lacking neuronal or endothelial nitric oxide synthases [DOI]
- 48 Participation of metabotropic glutamate receptors in pentetrazol-induced kindled seizure [DOI]
- 49 Intracellular aggregation of human stefin B: confocal and electron microscopy study [DOI]
- 50 Evaluation of anticonvulsant and nootropic effect of ondansetron in mice [DOI]
- 51 Theory and Practice of Histological Techniques [DOI]
- 52 Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1 [DOI]
- 53 Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway [DOI]
- 54 Emerging Mechanisms in Initiating and Terminating Autophagy [DOI]
- 55 Translational Control of Nrf2 Protein in Activation of Antioxidant Response by Oxidants [DOI]
- 56 Antiepileptic drugs and neuroprotection: Current status and future roles [DOI]
- 57 Nilotinib Attenuates Renal Injury and Prolongs Survival in Chronic Kidney Disease [DOI]
- 58 Neurochemical modulation involved in the beneficial effect of liraglutide, GLP-1 agonist on PTZ kindling epilepsy-induced comorbidities in mice [DOI]
- 59 Beneficial effects of nilotinib, tyrosine kinase inhibitor on cyclosporine-A induced renal damage in rats [DOI]
- 60 Antidepressant drugs in convulsive seizures: Pre-clinical evaluation of duloxetine in mice [DOI]
- 61 [Epilepsies and their medical treatment].
- 62 Relationship between drug-induced changes in seizure thresholds and the GABA content of brain and brain nerve endings [DOI]
- 63 Maternal hypoxia increases hippocampal cell susceptibility to ischemia after middle cerebral artery occlusion in rat offspring [DOI]
Cited by 0
No indexed citations yet.
Related research
- Neurodegenerative Observations on the Cerebral Cortex of Adult Wistar Rats Following Mercury Chloride Induced Cortical Damage in Adult Wistar Rats — shares topic coverage
- Morphological and Biochemical Effects of Aqueous Extract of Moringa oleifera Leaf on Cobalt Chloride-Induced Cerebral Damage in Adult Wistar Rats — shares topic coverage
- Solanum macrocarpon Leaf Extract Effects on Cerebral Cortex Microanatomy in Isoproterenol Induced Myocardial Infarction — shares topic coverage
- Effect of Ethanolic Extracts of Lemon Grass and Mango Bark on the Cerebral Astrocytes of Adult Wistar Rats — shares topic coverage
- Cortical White-matter Lesions as Initial Radiologic Finding in Carbon Monoxide Intoxication: A Case Report — shares topic coverage
Article metrics
Real usage data collected on this platform.
66
Page views
0
PDF downloads
28
Outbound clicks
0
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.