Neuroprotection Effects of Celastrus paniculatus Seed Oil against Monosodium Glutamate in Human IMR-32 Cells
Naumita Shah, Ankit Nariya, Ambar Pathan, Alpesh Patel, Shiva Shankaran Chettiar, Devendrasinh Jhala
Annual Research & Review in Biology · pp. 1–9 · Published 16 Feb 2018
10.9734/ARRB/2018/39256Abstract
Aims: The aim of this study is to evaluate the neuroprotective effects of Celastrus paniculatus seed oil (CPO) against monosodium glutamate in human IMR-32 cells. Study Design: Celastrus paniculatus seed oil used historically in Indian subcontinent for its neuro-enhancement property and also considered to have free radical scavenging activity. Methodology: In present study we have employed IMR-32, a neuroblastoma cells as our model system and utilized monosodium glutamate (MSG) a widely used food additive and proven inducer of free radicals to study the ameliorative effect of CPO against induced oxidative stress in neuronal cells. Results: Results showed that CPO ameliorates total protein level, decreases protein carbonyl and lipid peroxidation levels (p<0.001) as well as enhances the activity of superoxide dismutase and catalase (p<0.001) under oxidative stress conditions. Further we found that CPO increases the free radical scavenging capacity of cell by enhancing (p<0.001) glutathione level and help its regeneration by revitalizing the activity of glutathione peroxidase, glutathione S-transferase and glutathione reductase enzymes. Conclusion: It can be concluded that CPO has antioxidant property and proved to have ameliorative role against free radicals induced neuronal impairment.
Cited by 13
Sheikh Shohag, Shomaya Akhter, S. Islam · Oxidative Medicine and Cellular Longevity · 2022
S. Upadhyay, Y. Ahmad, S. Kohli · Indian journal of experimental biology · 2022
A. Al Hargan, M. Daghestani, A. Harrath · Brazilian journal of biology = Revista brasleira de biologia · 2021
Sri Rahayu, Riska Annisa, Ivakhul Anzila · Veterinary World · 2021
Naumita Shah, Ankit Nariya, A. Pathan · 2019
Naumita Shah, Ankit Nariya, A. Pathan · 2018
S. V, P. S., Velaman D · International journal of zoological investigations · 2023
Kim Wei Chan, V. Chin, N. Ismail · Multiple Biological Activities of Unconventional Seed Oils · 2022
Mohd Aleem · Journal of Complementary and Integrative Medicine · 2021
Showing 9 of 13 known citations — external sources report more than can currently be individually listed.
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