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Research Article Open access CC BY 4.0

Molecular Detection of Candida aaseri in Oral Cavity of Immunocompromised Patients

Saad J. Rashak, Marwan Y. Al-Maqtoofi, Ahmed A. Burghal

Asian Journal of Biology · pp. 91–97 · Published 28 May 2024

10.9734/ajob/2024/v20i6418

Abstract

The impaired human immune system, resulting from diabetes mellitus, can lead to the transition of Candida from a commensal to a pathogenic status, causing oral fungal infections. Candida aaseri is a dimorphic yeast with lipolytic activity which has not been previously reported in clinical infections. This study reports an extremely rare oral fungal infection associated with C. aaseri in a patient with type II diabetes mellitus. The patient, a 42-year-old female with diabetes mellitus type II from Basrah, Iraq, was and identified with a fungal oral infection. Swab samples were collected from the patient's oral cavity for microbial investigation and cultured on Sabouraud Dextrose Agar (SDA) at 37°C for 48 hours. The results revealed pure yeast growth. Blue colonies were observed on CHROMagar Candida. The genomic DNA of the isolated yeast was extracted for molecular-level diagnosis, utilizing the mRNA gene's internal transcribed spacer (ITS) region. C. aaseri was the sole yeast species identified in this clinical case. Anti-fungal sensitivity tests indicated that C. aaseri was sensitive to Nystatin, Posaconazole, and Fluconazole while exhibiting significant resistance to Colistin Sulfate. This study represents the first global report of isolating C. aaseri from an oral infection in an immunocompromised patient.

Antifungal Candida fungi oral infection immunocompromised ITS diabetes Basrah

References (18)

  1. 1 Amphotericin B and Other Polyenes—Discovery, Clinical Use, Mode of Action and Drug Resistance [DOI]
  2. 2 Oral manifestations in patients with diabetes mellitus [DOI]
  3. 3 Diagnosis and Treatment of Invasive Candidiasis [DOI]
  4. 4 Oral Cavity and Candida albicans: Colonisation to the Development of Infection [DOI]
  5. 5 COVID-19-associated opportunistic infections: a snapshot on the current reports [DOI]
  6. 6 Oral Candidiasis and Novel Therapeutic Strategies: Antifungals, Phytotherapy, Probiotics, and Photodynamic Therapy [DOI]
  7. 7 Rezafungin: A Novel Antifungal for the Treatment of Invasive Candidiasis [DOI]
  8. 8 Invasive Fungal Infections Among Immunocompromised Patients in Critical Care Settings [DOI]
  9. 9 Post-COVID-19 Fungal Infection in the Aged Population [DOI]
  10. 10 Detection of human pathogenic Fusarium species in hospital and communal sink biofilms by using a highly specific monoclonal antibody [DOI]
  11. 11 Candida albicans-Cell Interactions Activate Innate Immune Defense in Human Palate Epithelial Primary Cells via Nitric Oxide (NO) and β-Defensin 2 (hBD-2) [DOI]
  12. 12 High prevalence of Itraconazole Resistance among Candida parapsilosis isolated from Iran [DOI]
  13. 13 A Novel Flucytosine-Resistant Yeast Species, Candida pseudoaaseri, Causes Disease in a Cancer Patient [DOI]
  14. 14 Virulence factors of Candida species from the oral mucosa and prostheses of elderly people from a riverside community in the Amazon state, Brazil [DOI]
  15. 15 Immunodetection and risk assessment for Aspergillus contamination in nuts using a highly specific monoclonal antibody [DOI]
  16. 16 Draft Genome Sequence of a Lipolytic Yeast, Candida aaseri SH-14 [DOI]
  17. 17 Biological Activities of Natural Honey Produced In Basrah Governorate [DOI]
  18. 18 Incidence, antifungal resistance properties, and virulence traits of candida species isolated from HIV/AIDS Patients from the hospital system in Kenya [DOI]

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