Modulation of Immunological and Hematological Disturbances of Diabetes Mellitus by Diets Containing Combined Leaves of Vernonia amygdalina and Gongronema latifolium
Henry D. Akpan, Itemobong Ekaidem
Current Journal of Applied Science and Technology · pp. 534–544 · Published 7 Jan 2015
10.9734/BJAST/2015/14266Abstract
Background: Immunological and hematological alterations often occur in diabetes mellitus as a result of oxidative stress. This study investigated the effects of consumption of diets containing Vernonia amygdalina leaves on some markers of immunology and hematology in Streptozotocin -induced diabetic wistar rats with the view to evaluating its involvement in the management of immunological and hematological complications among diabetics. Method: The design consisted of eighty rats randomly divided into eight groups of 10 rats per group. Groups 2, 3, 4, 5, 6,7 and 8 were diabetic, while group 1 was normal control. Groups 1 and 2 were fed with control diet. Group 3 to 7 were fed with diets containing Vernonia amygdalina, or Gongronema latifolium or combined leaves of Vernonia amygdalina and Gongronema latifolium. Group 8 was fed with the control diet but treated with Insulin. Feed and water were given ad- libitum for 28 days. Results: Results showed that diabetic rats consuming diets of Vernonia amygdalina, Gongronema latifolium leaves or the combined leaves diets all had significant (P<0.05) increase in the red blood cell (RBC), hemoglobin, and lymphocyte counts relative to the diabetic control. All the diets resulted in significant (P<0.05) reduction in the level of white blood cell (WBC), platelets, neutrophil, and CD4+ cell count relative to the diabetic control. The results for Vernonia amygdalina and Gongronema latifolium diets were similar to insulin on the measured parameters and their levels were not significantly different (P<0.05) when compared to the normal control. Diets containing combined leaves of Vernonia amygdalina and Gongronema latifolium performed better than insulin and the measured parameters were numerically equals to the normal control. Conclusion: The findings of the present study indicate that consumption of diets containing Vernonia amygdalina or Gongronema latifolium leaves or in combination at the levels in this study have significant role in ameliorating hematological and immunological disturbances associated with diabetes mellitus. The combined leaf diet performed better due to positive synergy among the leaves bioactive agents. Consumption of diets containing Vernonia amygdalina or Gongronema latifolium leaves or in combination may be recommended as dietary therapies for management of immunological and hematological complications in diabetes mellitus.
References (21)
- 1 Global Burden of Diabetes, 1995–2025: Prevalence, numerical estimates, and projections [DOI]
- 2 High White Blood Cell Count Is Associated With a Worsening of Insulin Sensitivity and Predicts the Development of Type 2 Diabetes [DOI]
- 3 High Glucose-Induced Expression of Proinflammatory Cytokine and Chemokine Genes in Monocytic Cells [DOI]
- 4 White Blood Cell Count and Incidence of Coronary Heart Disease and Ischemic Stroke and Mortality from Cardiovascular Disease in African-American and White Men and Women: Atherosclerosis Risk in Communities Study [DOI]
- 5 The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE- , transferrin receptor 2-, and β 2 -microglobulin-deficient hepatocytes [DOI]
- 6 White Blood Cell Count Is Associated With Macro- and Microvascular Complications in Chinese Patients With Type 2 Diabetes [DOI]
- 7 The effect ofGongronema latifolium extracts on serum lipid profile and oxidative stress in hepatocytes of diabetic rats [DOI]
- 8 Antihyperglycemic effect of aqueous and ethanolic extracts of Gongronema latifolium leaves on glucose and glycogen metabolism in livers of normal and streptozotocin-induced diabetic rats [DOI]
- 9 Elevated White Blood Cell Count in Subjects With Impaired Glucose Tolerance [DOI]
- 10 Insufficient Glycemic Control Increases Nuclear Factor-κB Binding Activity in Peripheral Blood Mononuclear Cells Isolated From Patients With Type 1 Diabetes [DOI]
- 11 Comparative chemical composition of leaves of some antidiabetic medicinal plants: Azadirachta indica, Vernonia amygdalina and Gongronema latifolium [DOI]
- 12 Advanced glycation end products upregulate angiogenic and pro-inflammatory cytokine production in human monocyte/macrophages [DOI]
- 13 Changes in inflammatory biomarkers after successful lifestyle intervention in obese children.
- 14 An antimalarial extract from neem leaves is antiretroviral [DOI]
- 15 Proinflammatory blood monocytes: main effector and target cells in systemic and renal disease; background and therapeutic implications [DOI]
- 16 A proposed method for assessing plasma hypertonicity in vivo [DOI]
- 17 Increased secretion of TGF‐β1 by peripheral blood mononuclear cells from patients with Type 1 diabetes mellitus with diabetic nephropathy [DOI]
- 18 Production of Superoxide and Nitric Oxide by Granulocytes in Non-Insulin-Dependent Diabetic Patients With and Without Diabetic Nephropathy [DOI]
- 19 Reversal of cadmium induced toxicity following dietary supplementationwith garlic, ginger and cabbage in male Wistar rats
- 20 Evolution of a pulmonary insulin delivery system (Exubera) for patients with diabetes.
- 21 Early erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants [DOI]
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