Plasma 25-Hydroxy Vitamin-D and Risk of Breast Cancer: A Case Control Study

Abstract

Objective: To evaluate the association between low serum levels of 25 (OH)2 D and the risk of breast cancer among the female population. Methods: A prospective case control study was done, which recruited female patients with newly diagnosed breast cancer, follow up cases of treated breast cancers, and recurrent or metastatic breast cancer (Group A). Another group of control volunteers, presenting with benign breast diseases, in the surgical clinics was incorporated (Group B). Serum vitamin D levels of both groups were compared. Results: 50 patients were included in each group. Age ranged 21-76 years with a mean of 47.6 years. The levels of vitamin D in Group A were significantly lower than those in Group B (Odd ratio 55.5); two-tailed p value <0.05. This signified a substantial difference of vitamin D levels between the patients with established breast cancer and those not suffering from breast cancer. Conclusion: There is significant relation between breast cancer disease and low levels of vitamin D. This finding testifies the hypothesis that low serum levels of vitamin D plays an important role in the pathogenesis of breast cancer.