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Research Article Open access CC BY 4.0

Method Development for Chiral Purification of Racemic Clopidogrel Using Chiral Stationary Phase

Sangeeta Sangwan, Sharwan K. Dewan, Rajesh K. Thaper

International Research Journal of Pure and Applied Chemistry · pp. 19–30 · Published 19 Dec 2014

10.9734/IRJPAC/2015/14075

Abstract

HPLC method was developed for resolution of racemic clopidogrel into its chirally pure enantiomer of interest. Screening experiments were performed using amycoat and cellucoat analytical chiral stationary phases in organic solvent based polar and nonpolar eluents in various combinations. Based on the screening outcomes, the compound loading studies were carried out using amycoat higher µ particle sized chiral stationary column by keeping in mind the scale up studies to avoid high back pressure that can limit the efficiency of separation.  

Clopidogrel chromatography enantiomer preparative HPLC

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