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Research Article Open access CC BY 3.0

Metabolite Space of Rheumatoid Arthritis

Herman van Wietmarschen, Jan van der Greef

Journal of Advances in Medicine and Medical Research · pp. 469–483 · Published 11 Jul 2012

10.9734/BJMMR/2012/1577

Abstract

Metabolites play numerous roles in the healthy and diseased body, ranging from regulating physiological processes to providing building blocks for the body. Therefore, understanding the role of metabolites is important in elucidating the etiology and pathology of diseases and finding targets for new treatment options. Rheumatoid arthritis is a complex chronic disease for which new disease management strategies are needed. The aim of this review is to bring together and integrate information about the various roles that metabolites have in rheumatoid arthritis. An extensive PubMed search is conducted to collect the relevant manuscripts. The metabolites are discussed in relation to rheumatoid arthritis. Subsequently, the metabolites are organized according to levels of system organization. In the last section an integrated pathway analysis of the metabolites conducted with Ingenuity Pathway Analysis software is presented. Literature search resulted in information about vitamins, eicosanoids, fatty acids, lipids, hormones and peptides. The metabolites could be related to metabolic processes, oxidative stress processes and inflammatory processes. Cell death, lipid metabolism and small molecule biochemistry were found by the pathway analysis to be the top functions, characterized by the metabolites arachidonic acid, ascorbic acid, beta-carotene, cholecalciferol, hydrocortisone, keratan sulfate, melatonin, palmitic acid and stearic acid. These nine metabolites are highly connected to a number of canonical pathways related to immune functions, the production of nitric oxygen and reactive oxygen species in macrophages and pathways involved in arthritis. This review indicates groups of metabolites that could be interesting for metabolomics studies related to rheumatoid arthritis. Circadian rhythms of metabolite levels are found to be important for understanding and treating rheumatoid arthritis. In addition, some key processes and pathways are found by integrating the metabolite data. This might offer new ideas for studies into the mechanism of and possible treatment options for rheumatoid arthritis.

Rheumatoid arthritis metabolites systems biology health space diagnosis

References (65)

  1. 1 Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology [DOI]
  2. 2 Roles of PPARs in health and disease [DOI]
  3. 3 Guidelines for the management of rheumatoid arthritis: 2002 Update
  4. 4 Vitamin D intake is inversely associated with rheumatoid arthritis: Results from the Iowa Women's Health Study [DOI]
  5. 5 Visualization of omics data for systems biology [DOI]
  6. 6 Relationship of Animal Protein-Rich Diet to Kidney Stone Formation and Calcium Metabolism* [DOI]
  7. 7 New insights into the mechanisms of vitamin D action [DOI]
  8. 8 Anti-inflammatory effects of a low arachidonic acid diet and fish oil in patients with rheumatoid arthritis [DOI]
  9. 9 Collagen type II C-telopeptide fragments as an index of cartilage degradation [DOI]
  10. 10 Regulation of IGF-I function by proinflammatory cytokines: At the interface of immunology and endocrinology [DOI]
  11. 11 Lipids and inflammation: serial measurements of the lipid profile of blood donors who later developed rheumatoid arthritis [DOI]
  12. 12 Vitamin D in rheumatoid arthritis [DOI]
  13. 13 The Art and Practice of Systems Biology in Medicine: Mapping Patterns of Relationships [DOI]
  14. 14 High-density lipoprotein-associated apolipoprotein A-I: the missing link between infection and chronic inflammation? [DOI]
  15. 15 Relationship Between Disease Activity and Serum Levels of Vitamin D Metabolites and PTH in Rheumatoid Arthritis [DOI]
  16. 16 Changes in cartilage metabolism in arthritis are reflected by altered serum and synovial fluid levels of the cartilage proteoglycan aggrecan. Implications for pathogenesis. [DOI]
  17. 17 Vitamin D Endocrine System and the Immune Response in Rheumatic Diseases [DOI]
  18. 18 PLASMA-ZINC IN HEALTH AND DISEASE [DOI]
  19. 19 Atherogenicity of animal and vegetable protein [DOI]
  20. 20 Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer (Sweden) [DOI]
  21. 21 Lp(a) lipoprotein and lipids in patients with rheumatoid arthritis: serum levels and relationship to inflammation [DOI]
  22. 22 Rheumatoid arthritis and metal compounds—perspectives on the role of oxygen radical detoxification† [DOI]
  23. 23 Circadian rhythms in arthritis: Hormonal effects on the immune/inflammatory reaction [DOI]
  24. 24 Serum concentrations of α tocopherol, β carotene, and retinol preceding the diagnosis of rheumatoid arthritis and systemic lupus erythematosus [DOI]
  25. 25 Vitamin C and the risk of developing inflammatory polyarthritis: prospective nested case-control study [DOI]
  26. 26 Is the disease course of rheumatoid arthritis becoming milder?: Time trends since 1985 in an inception cohort of early rheumatoid arthritis [DOI]
  27. 27 Altered circadian rhythms in rheumatoid arthritis patients play a role in the disease's symptoms [DOI]
  28. 28 T-Lymphocytes: A Target for Stimulatory and Inhibitory Effects of Zinc Ions [DOI]
  29. 29 An investigation of the abnormal metabolic status of synovial fluid from patients with rheumatoid arthritis by high field proton nuclear magnetic resonance spectroscopy [DOI]
  30. 30 Urinary type II collagen helical peptide (HELIX‐II) as a new biochemical marker of cartilage degradation in patients with osteoarthritis and rheumatoid arthritis [DOI]
  31. 31 A comparative evaluation of the metabolic profiles of normal and inflammatory knee‐joint synovial fluids by high resolution proton NMR spectroscopy [DOI]
  32. 32 Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis. [DOI]
  33. 33 Serum total, HDL, LDL cholesterol, and triglyceride levels in patients with rheumatoid arthritis [DOI]
  34. 34 Rheumatoid arthritis, a complex multifactorial disease: On the way toward individualized medicine [DOI]
  35. 35 Biological rhythms in the inflammatory response and in the effects of non-steroidal anti-inflammatory drugs [DOI]
  36. 36 Challenges of predicting treatment response in patients with rheumatoid arthritis [DOI]
  37. 37 Ethnicity may be a reason for lipid changes and high Lp(a) levels in rheumatoid arthritis [DOI]
  38. 38 Regulation of insulin-like growth factor (IGF) II and IGF binding protein 3 autocrine loop in human PC-3 prostate cancer cells by vitamin D metabolite 1,25(OH)2D3 and its analog EB1089. [DOI]
  39. 39 Plasma zinc and copper concentrations in rheumatoid arthritis: influence of dietary factors and disease activity [DOI]
  40. 40 Application of markers of collagen metabolism in serum and synovial fluid for assessment of disease process in patients with rheumatoid arthritis. [DOI]
  41. 41 Nuclear magnetic resonance studies of synovial fluids from patients with rheumatoid arthritis and osteoarthritis [DOI]
  42. 42 Copper and Gold Salts in Rheumatoid Arthritis [DOI]
  43. 43 Neuroendocrine immune pathways in chronic arthritis [DOI]
  44. 44 The value of synovial fluid analysis in the assessment of knee joint destruction in arthritis in a three year follow up study [DOI]
  45. 45 Inhibition of antigen- and mitogen-induced human lymphocyte proliferation by gold compounds. [DOI]
  46. 46 SUPEROXIDE-DISMUTASE DEFICIENCY IN RHEUMATOID ARTHRITIS [DOI]
  47. 47 Zinc sulphate in rheumatoid arthritis [DOI]
  48. 48 Rheumatoid arthritis and the balance of dietary N-6 and N-3 essential fatty acids [DOI]
  49. 49 Lack of Beneficial Effect of Zinc Sulphate in Rheumatoid Arthritis [DOI]
  50. 50 The role of copper in inflammatory disorders [DOI]
  51. 51 HMDB: the Human Metabolome Database [DOI]
  52. 52 Integration of biological networks and gene expression data using Cytoscape [DOI]
  53. 53 Vitamin D and autoimmunity: new aetiological and therapeutic considerations [DOI]
  54. 54 Dietary fish oil and olive oil supplementation in patients with Rheumatoid Arthritis clinical and immunologic effects [DOI]
  55. 55 The influence of selenium on immune responses [DOI]
  56. 56 Circulating Oxidized LDL Is Associated With Subclinical Atherosclerosis Development and Inflammatory Cytokines (AIR Study) [DOI]
  57. 57 Circannual vitamin d serum levels and disease activity in rheumatoid arthritis: Northern versus Southern Europe.
  58. 58 Systems Biology Guided by Chinese Medicine Reveals New Markers for Sub-Typing Rheumatoid Arthritis Patients [DOI]
  59. 59 Adrenal secretion of cortisol in patients with rheumatoid arthritis.
  60. 60 Serum antioxidants and risk of rheumatoid arthritis. [DOI]
  61. 61 The interrelation of glutathione reductase, catalase, glutathione peroxidase, superoxide dismutase, and glucose-6-phosphate in the pathogenesis of rheumatoid arthritis [DOI]
  62. 62 Zinc in health and chronic disease.
  63. 63 Selenium Treatment in Rheumatoid Arthritis [DOI]
  64. 64 Calcitriol metabolism during chronic metabolic acidosis.
  65. 65 Antilipoprotein antibodies in rheumatoid arthritis [DOI]

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