Metabolic Effects of Probiotic Supplementation in Diabetic Hemodialysis Patients

Abstract

Aims: To evaluate the effects of probiotic supplementation in diabetic hemodialysis patients on metabolic profile and level of inflammation. Study Design: Single blind, placebo controlled clinical trial. Place and Duration of Study: Dialysis unit of internal medicine department, Tanta University, Egypt in a period between 1 st of January 2019 to 31 th march 2019. Methodology: 60 hemodialysis and diabetic patients were included. They were divided into two groups of equal numbers (Probiotics group and control group). Probiotic supplements were added to the Probiotics group, as regarding CBC parameters, lipid, iron profile, renal functions, HbA1c, serum albumin and CRP; we compared the base line values and values after the end of study in both groups. Results: There was significant increase in hemoglobin in study and control group at the end of study P value <0.001 in study group and P value <0.001 in control group, also significant decrease in CRP in study group P value <0.001, significant decrease in HbA1c in study group P value 0.001 and significant increase in serum albumin in study group P value 0.039. Conclusion: Although probiotics significantly improved the inflammation and glycemic control in diabetic hemodialysis patients, it had no significant effect in lipid and iron profile.