Mechanism and Clinical Aspects of the Effects of Chicory on Diabetes
Peyman S. Nowrouzi, Mohammad Mazani, Lotfollah Rezagholizadeh, Shokofeh Banaei
Asian Journal of Research in Medical and Pharmaceutical Sciences · pp. 1–11 · Published 18 Oct 2017
10.9734/AJRIMPS/2017/35273Abstract
At present, there is no cure for diabetes. However, due to the side effects of synthetic drugs, medicinal plants, have been variously used to treat it. One such anti-diabetic plant is chicory. The aim of this study is to review and summarize the clinical aspects and mechanisms of the effects of chicory and its products on the key factors involved in diabetes in different environments. Accordingly, it seems chicory is effective in almost all tissues and organs involved in blood sugar control. For instance, chicory has been shown to (i) inhibit the breakdown of disaccharides in the gastrointestinal tract and glucose absorption in the intestine, (ii) prevent the release of glucose from the liver, (iii) increase glucose uptake by the peripheral tissues, especially in muscles and the liver, (iv) stimulate insulin secretion from the pancreas, (v) enhance the insulin signaling pathways downstream and thereby reduce the diabetic complications. Consequently, blood glucose reduction after the administration of chicory is notable. The administration of chicory products appeared to have short-term and/or long-term effects on diabetes. This claim is approved by the results from the glucose tolerance test and HbA1c measurement. In addition, chicory fights against some primary agents responsible for diabetes and obesity. Since chicory reduces blood glucose and it has anti-diabetic effects, it is recommended that the involved mechanisms be investigated.
References (41)
- 1 The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM [DOI]
- 2 Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling [DOI]
- 3 THE INDIGENOUS DRUGS OF INDIA. [DOI]
- 4 Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine [DOI]
- 5 The International Diabetes Federation diabetes atlas methodology for estimating global and national prevalence of diabetes in adults [DOI]
- 6 Exercise regulation of glucose transport in skeletal muscle [DOI]
- 7 EFFECT OF GEL FIBRE ON GASTRIC EMPTYING AND ABSORPTION OF GLUCOSE AND PARACETAMOL [DOI]
- 8 Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin [DOI]
- 9 Anti-diabetic effects of Cichorium intybus in streptozotocin-induced diabetic rats [DOI]
- 10 Insulin resistance: a phosphorylation-based uncoupling of insulin signaling [DOI]
- 11 Regulation of Insulin Receptor Substrate 1 (IRS-1)/AKT Kinase-mediated Insulin Signaling by O-Linked β-N-Acetylglucosamine in 3T3-L1 Adipocytes [DOI]
- 12 Chicoric acid, a new compound able to enhance insulin release and glucose uptake [DOI]
- 13 Nitric Oxide Directly Promotes Vascular Endothelial Insulin Transport [DOI]
- 14 Ten Different Dietary Fibers Have Significantly Different Effects on Serum and Liver Lipids of Cholesterol-Fed Rats [DOI]
- 15 Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in ob/ob Mice [DOI]
- 16 Effects of insulin and exercise on muscle lipoprotein lipase activity in man and its relation to insulin action. [DOI]
- 17 Protein tyrosine phosphatases: the quest for negative regulators of insulin action [DOI]
- 18 The Water-Soluble Extract of Chicory Influences Serum and Liver Lipid Concentrations, Cecal Short-Chain Fatty Acid Concentrations and Fecal Lipid Excretion in Rats [DOI]
- 19 Dietary Soluble Fiber and Cholesterol Affect Serum Cholesterol Concentration, Hepatic Portal Venous Short-Chain Fatty Acid Concentrations and Fecal Sterol Excretion in Rats [DOI]
- 20 Dietary fibres: effects on lipid metabolism and mechanisms of action.
- 21 Effect of chicory seed extract on glucose tolerance test (GTT) and metabolic profile in early and late stage diabetic rats [DOI]
- 22 α-Glucosidase Inhibitory Activity of Triterpenoids from Cichorium intybus [DOI]
- 23 Alloxan diabetes-induced oxidative stress and impairment of oxidative defense system in rat brain: neuroprotective effects of cichorium intybus [DOI]
- 24 Chicory extracts from Cichorium intybus L. as potential antifungals [DOI]
- 25 Effects of the extract from roasted chicory (Cichorium intybus L.) root containing inulin-type fructans on blood glucose, lipid metabolism, and fecal properties [DOI]
- 26 Positive correlations of liver enzymes with metabolic syndrome including insulin resistance in newly diagnosed type 2 diabetes mellitus [DOI]
- 27 Caffeoylquinic acid-rich extract from chicory seeds improves glycemia, atherogenic index, and antioxidant status in rats [DOI]
- 28 Perspectives and utilization technologies of chicory ( Cichorium intybus L.): A review [DOI]
- 29 Hepatoprotective Activity of Cichorium intybus L. Leaves Extract Against Carbon Tetrachloride Induced Toxicity [DOI]
- 30 Inhibition of protein tyrosine phosphatase 1B and regulation of insulin signalling markers by caffeoyl derivatives of chicory (Cichorium intybus) salad leaves [DOI]
- 31 Hypoglycemic effect of Swietenia macrophylla seeds against type II diabetes [DOI]
- 32 Dynamics of Protein-tyrosine Phosphatases in Rat Adipocytes [DOI]
- 33 The Water-Soluble Extract of Chicory Reduces Glucose Uptake from the Perfused Jejunum in Rats [DOI]
- 34 Antihepatotoxic activity of Cichorium intybus [DOI]
- 35 Nitric oxide and insulin resistance [DOI]
- 36 THE EFFECT OF DIABETES AND FASTING ON LIVER GLUCOSE-6-PHOSPHATASE [DOI]
- 37 Modulatory effect of an isolated compound fromSyzygium cuminiseeds on biochemical parameters of diabetes in rats [DOI]
- 38 The Vascular Endothelium, a Benign Restrictive Barrier? NO! Role of Nitric Oxide in Regulating Insulin Action [DOI]
- 39 Studies of Liver Glucose 6-Phosphatase [DOI]
- 40 Higher Levels of Alanine Aminotransferase Within the Reference Range Predict Unhealthy Metabolic Phenotypes of Obesity in Normoglycemic First‐Degree Relatives of Patients With Type 2 Diabetes Mellitus [DOI]
- 41 ANTI-DIABETIC ACTIVITY OF METHANOLIC EXTRACT OF CHICORY ROOTS IN STREPTOZOCIN INDUCED DIABETIC RATS
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