Mandibular Langerhans Cell Histiocytosis Presenting with Gingivitis: A Case Report and Literature Review
Yeşim Çağlar, Enes Dalmanoğlu, Berat Karaman
International Journal of Medical and Pharmaceutical Case Reports · pp. 120–126 · Published 24 Dec 2025
10.9734/ijmpcr/2025/v18i4470Abstract
Langerhans cell histiocytosis (LCH) is a rare hematological disorder that may present in the oral cavity. Intraoral LCH lesions may present as masses, gingivitis, ulcers, gingival bleeding, tooth loss, pain, cysts, leukoplakia or non-healing wounds after surgery or tooth extraction. A multidisciplinary approach involving imaging, biopsy, and immunohistochemical analysis is essential for early diagnosis and management. This case underscores the diagnostic challenges and the importance of timely intervention. This report presents a 47-year-old male with persistent mandibular pain and gingival inflammation which was initially considered to be complicated by osteomyelitis. Biopsy confirmed the diagnosis of LCH. The case highlights the importance of considering LCH in the differential diagnosis of atypical mandibular lesions in adults.
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