Low Plasma Iron Levels Associated to Drug Treatment in Polymedicated Patients: A Case-Control Study
R. Lozano, A. Frutos, Frutos, Alberto, A. Apesteguía, Martinez, Alejandro, A Martinez, M. E. Franco, M. A. Alcazar, Lozano, Roberto
Journal of Advances in Medical and Pharmaceutical Sciences · pp. 23–28 · Published 28 Dec 2020
10.9734/jamps/2020/v22i1030197Abstract
Aim: To identify the drug class and/or duration of treatments causing hyposideremia. Study Design: Retrospective case-control study. Place and Duration of Study: Departments of Internal Medicine and Pharmacy, Aragón Health Services Services Hospital Real de Nuestra Señora de Gracia, between January 2019 and December 2019. Methodology: The records of prescripted medicines of all patients admitted to Internal Medicine service, for various indications, along a 1-year period (2019), which were ultimately analized according to association with hyposideremia. Results: It was identified several drugs associated with low plasma iron levels: acetylcysteine and apixaban, which would increase the risk of hyposideremia. On the contrary, we found that allopurinol, duloxetine and simvastatin would protect against the appearance of hyposideremia. Conclusion: Acetylcysteine and apixaban, alone or in combination with different pathologies, would be capable of inducing, and on dependence of the duration of treatment and/or of the concomitant pathology, hyposideremia, iron deficiency and, in certain cases, anemia constituting a major health problem.
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