Long-Term Mortality of 306,868 Patients with Multi-Vessel Coronary Artery Disease: CABG versus PCI
Jimmy T. Efird, Wesley T. O’ Neal, Stephen W. Davies, Whitney L. Kennedy, Lada N. Alger, Jason B. O’Neal, T. Bruce Ferguson, Alan P. Kypson
Journal of Advances in Medicine and Medical Research · pp. 1248–1257 · Published 2 Apr 2013
10.9734/BJMMR/2013/3380Abstract
Background: Several randomized controlled trials (RCT) have reported no difference in long-term mortality between coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI). The purpose of this pooled observational analysis was to compare recent retrospective studies examining long-term survival of patients with multi-vessel coronary artery disease undergoing CABG and PCI. Methodology: We searched Medline for observational studies comparing long-term (>1 year) survival between CABG and PCI for the treatment of multi-vessel coronary artery disease over the past 10 years. Results: Eight studies met inclusion criteria. A total of 306,868 patients (155,502 CABG; 151,366 PCI) were identified. Follow-up ranged from 1 to 8 years. Mantel-Haenszel combined hazard ratios (HR) for mortality demonstrated a protective benefit of CABG compared with PCI (HR=0.77, 95%CI=0.75-0.79). Conclusion: These findings suggest a long-term survival advantage for CABG compared with PCI in patients with multi-vessel coronary artery disease.
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