Research Progress in Fluorinated Isoquinoline-1,3-diones

References (29)

1. 1 Purser, 2008, Fluorine in medicinal chemistry [DOI]
2. 2 Muller, 2007, Fluorine in pharmaceuticals: Looking beyond intuition [DOI]
3. 3 Schlosser, 2006, CF3-bearing aromatic and heterocyclic building blocks [DOI]
4. 4 Ma, 2007, Strategies for nucleophilic, electrophilic, and radical trifluoromethylations [DOI]
5. 5 Chen, 2012, The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus [DOI]
6. 6 Snow, 2002, Discovery of 2-Phenylamino-imidazo[4,5-h]isoquinolin-9-ones: A New class of inhibitors of Lck kinase [DOI]
7. 7 Vernekar, 2015, Design, synthesis, biochemical, and antiviral evaluations of C6 Benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: Dual inhibition against HIV reverse transcriptase-associated R Nase H and polymerase with antiviral activities [DOI]
8. 8 Billamboz, 2011, Magnesium chelating 2-hydroxyiso- quinoline-1,3(2H,4H)-diones, as inhibitors of HIV-1 integrase and/or the HIV-1 reverse transcriptase ribonuclease H domain: Discovery of a novel selective inhibitor of the ribonuclease H function [DOI]
9. 9 Kankanala, 2016, Isoquinoline-1,3-diones as selective inhibitors of tyrosyl DNA phosphodiesterase II (TDP2) [DOI]
10. 10 Tsou, 2009, Discovery of 4-(benzylaminomethylene) isoquinoline-1,3-(2H,4H)-diones and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4 [DOI]
11. 11 Kong, 2013, Metal-free aryltrifluoromethylation of activated alkenes [DOI]
12. 12 Li, 2014, Metal-free direct intramolecular carbotrifluoromethylation of alkenes to functionalized trifluoromethyl azaheterocycles [DOI]
13. 13 Deng, 2016, Radical-mediated divergent cyclization of benzamides toward perfluorinated or cyanated isoquinolinediones [DOI]
14. 14 Zhang, 2025, Vanadium-Catalyzed Trifluoromethylation/Cyclization of Alkenes and 1,7-Enynes with Togni-II Reagent to Access Trifluoromethylated Oxindoles, Isoquinoline-1,3-diones, and Indeno[1,2-c]quinolines [DOI]
15. 15 Liu, 2015, Light-induced BiOBr nanosheets accelerated highly regioselective intermolecular trifluoromethylation/arylation of alkenes to synthesize CF3-containing aza-heterocycles [DOI]
16. 16 Zheng, 2015, Difunctionalization of alkenes via the visible-light-induced trifluoromethylarylation/1,4-aryl shift/desulfonylation cascade reactions [DOI]
17. 17 Tang, 2015, Synthesis of perfluorinated isoquinolinediones through visible-light-induced cyclization of alkenes [DOI]
18. 18 Deng, 2016, Visible-light-induced cascade addition cyclization of alkenes toward perfluoroalkylated isoquinolinediones
19. 19 Zou, 2017, Visible-light induced di-and trifluoromethylation of N-benzamides with fluorinated sulfones for the synthesis of CF2H/CF3-containing isoquinolinediones [DOI]
20. 20 Lu, 2018, Synthesis of oxindoles through trifluoromethylation of N-aryl acrylamides by photoredox catalysis [DOI]
21. 21 Zuo, 2019, Metal-free visible-light photocatalytic tandem radical addition-cyclization strategy for the synthesis of sulfonyl-containing isoquinolinediones [DOI]
22. 22 Wang, 2019, Metal-free, Visible-Light-Induced Radical Trifluoromethylation/Cyclization of N-benzamides with CF3SO2Na to Synthesize CF3-Containing Isoquinoline-1,3-diones [DOI]
23. 23 Chen, X., Liu, Q., and Wang, Z. (2021). Synthesis Method of Trifluoromethyl Reagent and Its Application in Preparation of Trifluoromethylated Product. (China Patent CN113861240A).
24. 24 Liu, 2021, Visible-Light-Induced Selective Photolysis of Phosphonium Iodide Salts for Monofluoromethylations [DOI]
25. 25 Zhang, 2019, Mn-mediated electrochemical tyrifluoromethylation/C(sp2)-H functionalization cascade for the synthesis of azaheterocycles [DOI]
26. 26 Yuan, 2021, Electrochemical Tri-and Difluoromethylation-Triggered Cyclization Accompanied by the Oxidative Cleavage of Indole Derivatives [DOI]
27. 27 Guo, 2021, Electrochemical trifluoromethy- lation/cyclization for the synthesis of isoquinoline-1,3-diones and oxindoles [DOI]
28. 28 Chen, 2023, Electrophotocatalytic tri- or difluoromethylative cyclization of alkenes [DOI]
29. 29 Liu, A., Wang, J., and Wang, G. (2025). An Electrochemical Preparation Method for the Synthesis of Fluoro-Substituted Isoquinoline-1,3-dione Compounds via Trifluoromethylation Cyclization. (China Patent CN115747843B).

Cited by 0

No indexed citations yet.

Related research

• A Novel Catalytic Synthesis of Flavones under Autoclave Conditions and Comparative Study of Anti-cancer Activity — shares topic coverage
• Thermostability and in-vitro Antibacterial Activity of Aqueous Extracts of Tetrapleura tetraptera Pods on Multidrug Resistant Clinical Isolates — shares topic coverage
• Acute Toxicity, Phytochemistry and Anti-diarrheal Effects of Celtis integrifolia Lam. Aqueous Leaf Extract in Wistar Albino Rats — shares topic coverage
• Understanding the Reactivity of Trimethylsilyldiazoalkanes Participating in [3+2] Cycloaddition Reactions towards Diethylfumarate with a Molecular Electron Density Theory Perspective — shares topic coverage
• Understanding the Origin of the Regioselectivity in Non-Polar [3+2] Cycloaddition Reactions through the Molecular Electron Density Theory — shares topic coverage