Melanoma of Unknown Primary Presenting with Hepatic and Cerebral Metastases: A Case Report

Abstract

Malignant melanoma is a highly metastatic tumour that develops at the expense of melanocytes.The most common sites of metastasis are the liver, brain and lungs, and in most cases the primary site can be determined.Metastasis of melanoma with an unknown primary site poses a diagnostic and therapeutic challenge for clinicians due to its rarity.A positive diagnosis and the decision on optimal treatment are based primarily on immunohistochemical studies and molecular biological analysis.We report the case of a patient with liver and brain metastases from a melanoma of undetermined origin. Despite immunotherapy with ipilimumab and nivolumab, the patient's condition progressed rapidly and unfavourably, highlighting the complexity and lack of standardised recommendations for therapeutic management.Understanding the difficulties associated with managing this type of case is crucial, as it paves the way for further research.