A Rare Case of Crohn’s Disease Associated with Peutz-Jeghers Syndrome

Abstract

In this report, we present a case of a 28-year-old female patient who had both Peutz-Jeghers syndrome and Crohn's disease. Peutz-Jeghers syndrome is a rare genetic disorder with autosomal dominant transmission characterized by the association of hamartomatous polyposis and cutaneous mucosal pigmented macules predominantly around the mouth and on the lips. Its incidence is approximately one in every 50,000 people. Crohn's disease, on the other hand, is a chronic inflammatory bowel disease that progresses to intestinal destruction, and its incidence is on the rise. We believe this case to be the fourth documented case in the world of Peutz-Jeghers syndrome coinciding with Crohn's disease. The association between PJS and Crohn's disease is infrequent. The risk of malignancy, especially digestive cancer, is the common point between these two pathologies. Screening is most important. The risk of extra digestive neoplasia in the context of PJS makes the therapeutic management of Crohn's disease more difficult.