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The Serological Basis of the Correlation between Iron Deficiency Anemia and Thyroid Disorders in Women: A Community Based Study

Riazul Islam, Kazi Mahmuda Akter, Atikur Rahman, Nurun Nahar Khanam, Salauddin Al Azad, Md. Raihanul Islam, Mithila Farjana, Mohammad Habibur Rahman, Md. Nasir Uddin Badal, Sharmin Ahmed, . Assaduzzaman

Journal of Pharmaceutical Research International · pp. 69–81 · Published 30 Mar 2021

10.9734/jpri/2021/v33i19A31330

Abstract

Objectives: Iron Deficiency Anemia (IDA), a global public health problem may have an inimical effect on thyroid function, especially in women and children. This study was conducted to inspect the correlation between IDA and thyroid disorders in women of Bangladesh. Methods: A cross-sectional study was conducted among 452 women of different age groups in particular regions of Bangladesh presenting anemic symptoms and were confirmed anemic after testing of serum hemoglobin levels less than 12 g/dL. To identify the correlation between iron deficiency anemia and thyroid disorders; serum samples were tested quantitatively through standardized methods considering serum iron, total iron-binding capacity (TIBC), ferritin, thyroid-stimulating hormone (TSH), free thyroxin (FT4), and vitamin D levels as parameters. Post clinical diagnosis statistical analysis, graphical presentations of the complex clinical data was generated using advanced computer programming language and bio-analytical tools.   Results: A positive correlation between hypothyroidism and IDA in women was discovered in this study as 24.69% of patients with IDA from 0-60 years were found suffering from hypothyroidism simultaneously; with the highest percentage (38.46%) amongst the 31-40 years of age and 26% of iron-deficient females of reproductive age (15-49 years) were suffering from hypothyroidism. Moreover, the association between congenital hypothyroidism and IDA was noticed in 50% of cases above all. Conclusion: Hypothyroidism was found quite common among the women of different age groups who were previously reported with acute to chronic anemia symptoms due to iron deficiency. 

Iron Deficiency Anemia (IDA) hypothyroidism Thyroid-Stimulating Hormone (TSH) Total Iron-Binding Capacity (TIBC) ferritin Free Thyroxin (FT4) reproductive age and congenital hypothyroidism

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