Novel Synthetic Derivatives of Sydnones and Elucidation of Biological Applications

Abstract

The heterocyclic compounds have been effectively utilised as clinical agents among the various synthesised chemotherapeutic medicines. In synthetic chemistry, several of these are also useful intermediates. Because of their structure, chemical behaviour, and diverse pharmacological characteristics, the "Mesoionic" chemicals have garnered interest among the enormous number of non-benzenoid heterocycles known. The "Sydnones," which are being explored for their pharmacological characteristics and have lately been widely employed as synthons, are the most thoroughly studied class of mesoionic chemicals. Sydnones are one of the most well investigated mesoionic chemicals for cycloaddition processes. Despite their chemical stability and adaptability, only a few research groups have studied their chemistry and applications in organic synthesis. The research was carried out on a variety of sydnones. The analytical laboratory results have revealed on the synthesis and biological characteristics of a vast number of sydnone derivatives combined with physiologically active heterocycles; however none of them has progressed to the clinical stage. As a result, we attempted to construct various heterocycles on the sydnone ring in order to conducting structure-activity relationship (SAR) research.