The Rhizome of Curculigo pilosa Exerts Hepatoprotective and Nephroprotective Effects in Rats Exposed to Acetaminophen Toxicity

Abstract

Aims: The exposition of drug-induced hepatotoxicity and nephron injury is highly uneven; some range from asymptomatic but elevated liver and kidney parameters to meteoric liver and kidney damage. The medicinal plants have been exploited for fighting toxicity, but their mechanisms remain unexplored. The purpose of this study was to see how an aqueous extracts of Curculigo pilosa (C. pilosa) rhizome affected the hepato- and nephro-toxicity caused by 750 mg/kg and 1000 kg/mg body weight doses of acetaminophen (APAP) in rats. Methodology: Thirty (30) female rats used for this study were divided into six groups (n = 5). Group A served as control. C. pilosa (300 mg/kg body weight) was given to Group B. Group C was administered a 750 mg/kg body weight dose of APAP. Group D was administered a 750 mg/kg body weight APAP dose plus 300 mg/kg body weight of an aqueous extracts of C. pilosa. A 1000 mg/kg body weight APAP dose was given to Group E. Group F was administered APAP (dose 1000 mg/kg body weight) plus an aqueous extracts of C. pilosa (300 mg/kg body weight). The serum concentrations of urea, creatinine, chloride, potassium, sodium, alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) were analyzed using standard methods. Results: The APAP-induced toxicity caused a significant (P=.05) increase in the levels of ALT, AST, ALP, creatinine, urea, potassium, sodium, and chloride, but treatment with an aqueous extracts of C. pilosa rhizome significantly (P=.05) decreased the levels of these markers compared to the control. Conclusion: The aqueous extracts of C. pilosa rhizome has hepatoprotective and nephroprotective effects against APAP-induced toxicity.