Non-traditional Route for Three Antifungal Drugs in Fungal Keratitis Treatment
Christine R Sedhom, Mohamed S Abdel-Rahman, Mohamed S Hussein
Ophthalmology Research: An International Journal · pp. 1–11 · Published 11 Jun 2019
10.9734/or/2019/v10i230104Abstract
Aims: This study aims to evaluate the efficacy of the intrastromal route of antifungal drugs in treatment of fungal keratitis. Study Design: Prospective non-controlled (single arm) interventional clinical study Place and Duration of Study: Ophthalmology Department, Assiut University Hospital, between March 2016 to November 2017. Methodology: Corneal scrapings for direct smears and cultures were done for eighteen eyes of 18 consecutive patients and intrastromal injections were given according to sensitivity results. Results: After one month of follow up of the cases in this study, 33.3% of the cases had rapid complete cure and the rest had incomplete cure with resolution of ulcer sizes by 55.34% ±6.78 after one or more intrastromal injection of antifungal drugs. Conclusion: Intrastromal injection of antifungal drugs in treatment of fungal keratitis shows promising results in advanced cases of fungal keratitis when combined with the topical route.
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