Ivoirian Molecular Profile of High-risk Human Papillomavirus: Preliminary Study of 250 Cases in a Single Center in Abidjan

Abstract

Background: The carriage of high-risk papillomavirus (HR-HPV) differs between countries and regions of the world. There is not enough data on the genotyping of this virus in Côte d'Ivoire and in Abidjan particularly. Aim: to illustrate the genotypes of prevalent HR-HPV in the city of Abidjan. Materials and Methods: Descriptive cross-sectional study, carried out over a period of 2 months at the Teaching Hospital of Yopougon. It involved endocervical swabbing of 250 sexually active women. The HPV genotyping was performed by real-time PCR. A logistic regression made it possible to determine the factors associated with the carriage of HPV. Results: The mean age of the population was 43.33 and a prevalence of 34% was found. HPV 68 was the most prevalent (18.1%) followed respectively by HPV 52 (17.2%), HPV 56 (13.8%), HPV 35 (8.6%), HPV 45 (7.0%). As for genotypes 16 and 18, they only represented 2.5% and 5.1% respectively. The prevalence of multiple infections was 24.6%. The associated factors to the HPV infection were the educational level OR= 0.45; IC 95% [0.24-0.85] and the marital status OR = 0.40; IC 95% [0.20-0.79]. Conclusion: The prevalence of HPV was high, and the genotypes identified are different from those targeted by the currently available prophylactic vaccines. The management with an appropriate vaccine is therefore necessary for these West African countries.