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Research Article Open access CC BY 4.0

Investigation of Hypoglycemic and Hypolipidemic Effects of Methanolic Extracts of Bitter Leaf [Vernonia amygdalina Delile] in Male Rats

Kazeem B. Bawa, Ayobola A. Iyanda

Asian Journal of Advanced Research and Reports · pp. 30–37 · Published 1 Jun 2020

10.9734/ajarr/2020/v10i430250

Abstract

Different agents used for treatment of diabetes mellitus are associated with serious adverse effects. This necessitates the scientific quest for substitutes that are comparatively less noxious- usually medicinal plants (e.g. Vernonia amygdalina Delile). Diabetes was induced in rats in groups A-D using alloxan. Group E served as control. Once daily for 28 days, diabetic rats in groups B and C were treated with 50 & 100 mg/kg BW of methanolic extracts of Vernonia amygdalina respectively while group D rats were administered with metformin hydrochloride (250 mg/Kg BW). Rats in group A served as untreated diabetic group. Fasted blood samples were collected for estimation of fasting blood glucose (FBG); total cholesterol (TC), triglyceride (TG), and high density lipoprotein-cholesterol (HDL-C) using standard biochemical methods. Statistical analysis was carried out using Student’s t test, P<0.05 was considered significant. After treatment, there were significant decreases in levels of FBG, TC, TG, LDL-C but increase level of HDL-C of B, C, & D when compared with group A. results of the study suggest that methanolic extract of V. amygdalina possesses antidiabetic properties and anti-hypolipidemic effects; this may explain why this plant is traditionally used for the management of diabetes mellitus and its complications.

Vernonia amygdalina diabetes mellitus lipid profile blood glucose.

References (16)

  1. 1 Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge [DOI]
  2. 2 Medicinal plants of India with anti-diabetic potential [DOI]
  3. 3 The role and place of medicinal plants in the strategies for disease prevention [DOI]
  4. 4 Advances in selected medicinal and aromatic plants indigenous to Africa. [DOI]
  5. 5 Antidiabetic effect of total saponins from Entada phaseoloides (L.) Merr. in type 2 diabetic rats [DOI]
  6. 6 An analytical review of plants for anti diabetic activity with their phytoconstituent & mechanism of action.
  7. 7 Prevalence of and Risk Factors for Type 2 Diabetes Mellitus in Hyperlipidemia in China [DOI]
  8. 8 Appropriate Insulin Level in Selecting Fortified Diet-Fed, Streptozotocin-Treated Rat Model of Type 2 Diabetes for Anti-Diabetic Studies [DOI]
  9. 9 RETRACTED ARTICLE: Enhanced glycemic control, pancreas protective, antioxidant and hepatoprotective effects by umbelliferon-α-D-glucopyranosyl-(2I → 1II)-α-D-glucopyranoside in streptozotocin induced diabetic rats [DOI]
  10. 10 Potential impact of Paracentrotus lividus extract on diabetic rat models induced by high fat diet/streptozotocin [DOI]
  11. 11 In vitro antimicrobial activities of Vernonia amygdalina on selected clinical isolates
  12. 12 Antidiabetogenic action of Morus rubra L. leaf extract in streptozotocin-induced diabetic rats [DOI]
  13. 13 Saponin as regulator of biofuel: implication for ethnobotanical management of diabetes [DOI]
  14. 14 Validation of the antidiabetic effects of Vernonia amygdalina delile leaf fractions in fortified diet-fed streptozotocin-treated rat model of type-2 diabetes [DOI]
  15. 15 Effect of combined use of Ocimum gratissimum and Vernonia amygdalina extract on the activity of angiotensin converting enzyme, hypolipidemic and antioxidant parameters in streptozotocin-induced diabetic rats [DOI]
  16. 16 Phytochemical constituents and ethnobotany of the leaf extract of bitter leaf (Vernonia amygdalina) Del [DOI]

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