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Research Article Open access CC BY 4.0

Investigating the Anti-diabetic and Lipid-regulating Properties of Eclipta alba in Alloxan-induced Diabetes

FM. Sharifuzzaman Shohan, Susmoy Dey, Tasin Islam Pranto, Md. Rahmat Ullah, Sadia Tasnim, Juliana Aditi Baroi, Israt Jahan Rasna

Journal of Complementary and Alternative Medical Research · pp. 115–123 · Published 15 Jan 2025

10.9734/jocamr/2025/v26i1618

Abstract

Since the dawn of human civilization, humanity has used herbal medicine for medicinal purposes. Traditional medicine has experienced a substantial surge in popularity in recent years. This research sought to evaluate the antidiabetic effectiveness and lipid profile of Eclipta alba. We evaluated the antidiabetic efficacy using the alloxan-induced diabetic model. The dosages of 800 mg/kg and 1200 mg/kg in groups 5 and 6, respectively, yielded statistically significant findings (p < 0.05) regarding antidiabetic efficacy. The group receiving a 1200 mg/kg dosage had statistically significant outcomes for total cholesterol and LDL, with findings of 196.15 ± 8.91* and 123.77 ± 6.50*, respectively (p < 0.05). However, no groups exhibited statistically significant results for HDL and triglyceride levels, despite a reduction in these parameters in the blood after the administration of the extract. Group 6, with a dosage of 1200 mg/kg, exhibited statistically significant results (p < 0.05) for SGPT and SGOT, with values of 88.71 ± 6.23* and 92.82 ± 7.50*, respectively. In the kidney function test, groups 5 and 6 exhibited statistically significant results (p < 0.05) at doses of 800 and 1200 mg/kg. So ethanolic extract of this plant shows significant antidiabetic and antihyperlipidemic activity and further advanced research on this plant may add alternative medicine to the treatment system.

Eclipta alba HDL LDL diabetes herbal medicine triglyceride

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