Integrins and Reorganization of Osteoclast Cytoskeleton under Orthodontic Force
Jie Feng, Yang Xu, Li Xu, Qiuyue Guan, Zheng Wang, Ding Bai, Xianglong Han
Journal of Advances in Medicine and Medical Research · pp. 1–8 · Published 17 Jul 2015
10.9734/BJMMR/2015/19544Abstract
Integrins are mechanoreceptors and mediate mechanotransduction by transferring forces into focal adhesions. Osteoclastogenesis starts with adhesion to the bone matrix, leading to cytoskeleton reorganization that is important for osteoclast polarization and migration. However, there are several signaling pathways mediating this process, and integrins have been shown to be important signaling molecules participating osteoclastogenesis. Particularly, integrins have played an important role in both force transduction and osteoclastogenesis. This paper reviewed the findings on the relationship between integrins and reorganization of osteoclast cytoskeleton under orthodontic force.
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