Influence of Lycopene on Renal Tissue Injury in Celebrex Induced Albino Rats; An Experimental Research Study

Abstract

Objective: To analyze the renal tissue injury in Celebrex induced albino rats with improvement by lycopene.  Study design: Experimental research study. Abode of study: Animal House, Basic medical sciences institute, Karachi, Materials and Methods: Celebrex and antioxidant agent lycopene were used in this experimental study. Drugs were administered orally to forty male albino rats weighing of around 250gm for research. Rats were retained in isolated cages and alienated into 4 sets including control, diseased, treated groups. The drugs were administered by gastric tube once24-hourly for four weeks.  After finalization of research work, rats were sacrificed and body tissues were preserved for staining. Results: gB Gomori’s calcium phosphate stained sections showed marked deposition of dark black particles of alkaline phosphate in cellular cytoplasm of proximal convoluted tubules but gC showed scarce deposition of black particles of alkaline phosphate in the cellular cytoplasm of proximal convoluted tubules. Conclusion: This experiment discloses that lycopene recuperate the raised level of alkaline phosphate in the cytoplasm of proximal convoluted tubules.