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Research Article Open access CC BY 4.0

In vitro Anti-inflammatory Evaluation of African Nutmeg (Monodora myristica) Seeds

K. F. Akinwunmi, O. O. Oyedapo

European Journal of Medicinal Plants · pp. 167–174 · Published 30 Apr 2015

10.9734/EJMP/2015/17853

Abstract

Aim: To determine the anti-inflammatory potential of flavonoid rich fraction of Monodora myristica seeds. Study Design: In vitro evaluation of anti-inflammatory assays: Membrane stability, Inhibition of denaturation of albumin and lipoxygenase inhibition. Place and Duration: Department of Biochemistry, Obafemi Awolowo University, Ile-Ife, Nigeria (May–November, 2014). Methodology: Flavonoid rich fraction of the seeds of M. myristica was obtained from the ethanol extract of M. myristica seeds by solvent partitioning. Standard methods were employed in the anti-inflammatory assays (Membrane stability, Inhibition of denaturation of albumin and lipoxygenase inhibition). Results: Flavonoid rich fraction of M. myristica exhibited significant in vitro anti-inflammatory potentials by stabilizing red blood cell membrane exposed to hypotonic and heat induced lyses with maximum percentage stability of 88±0.45% in a biphasic mode of response that is comparable with Ibuprofen a standard anti-inflammatory drug. It also inhibits heat induced albumin denaturation with maximum inhibition of 75.38±0.56% in a concentration dependent manner that is comparable with aspirin. Flavonoid rich fraction of M. myristica showed an anti-lipoxygenase activity range from 19±1.28% to 71±2.13% which is comparable to that produced by indomethacin. Conclusion: The result obtained in the present investigation indicates that flavonoid rich fraction of M. myristica could be a potential source of anti-inflammatory agent. This substantiates the role of M. myristica seeds as a natural source of anti-inflammatory agent.  

Monodora myristica anti-inflammatory denaturation membrane stability red blood cells (RBC)

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